Study On The Correlation Between GDF15、PTX3 And Coronary Slow Flow

Objective:To observe and analyze the correlation between growth differentiation factor 15(GDF15),positive pentamer protein 3(PTX3),and coronary slow blood flow(CSF),in order to provide theoretical basis for the possible pathogenesis and diagnosis of coronary slow blood flow(CSF).Methods:The patients hospitalized in the Department of Cardiology,Yijishan Hospital,Wannan Medical College due to precordium discomfort(chest pain or chest tightness)from June 2021 to December 2022 were selected.During hospitalization,coronary angiography showed that there was no obvious stenosis of epicardial coronary artery(stenosis degree<40%),but there was slow flow in at least one coronary artery(corrected TIMI frame number(CTFC)≥27 frames of coronary artery).The total number of patients was 40,Among them,there are 21 males and 19 females;At the same time,42 patients with normal coronary artery angiography during the same period(coronary artery stenosis degree<40%and CTFC<27 frames)were randomly selected as the control group,including 22 males and 20 females.Collect basic data,blood routine,biochemical,electrocardiogram,and other clinical data of two groups of patients,and detect and record the data of GDF15 and PTX3 in both groups of patients;Afterwards,SPSS 25.0 was used for statistical analysis of the two groups of data,t-test was used for inter group measurement data,chi square(x)test was used for inter group count data,unconditional logistic regression was used to analyze independent risk factors for CSF,Pearson correlation analysis was used to analyze the correlation between CTFC and GDF15,and the diagnostic value of relevant indicators for CSF was analyzed by drawing the receiver operating characteristic curve(ROC curve),The difference was statistically significant with P<0.05.Results:(1)There was no significant difference in gender,age,body mass index(BMI),hypertension,diabetes history and smoking history between the two groups(P>0.05).(2)The platelet distribution width(PDW),red blood cell volume distribution width(RDW),neutrophil/lymphocyte ratio(NLR),triglycerides(TG),hypersensitive C-reactive protein(hs CRP),and uric acid(UA)of patients in the CSF group were significantly higher than those in the control group(P<0.05);The level of high-density lipoprotein cholesterol(HDL-C)was significantly lower than that of the control group(P;There was no statistically significant difference in total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels between the two groups of patients(P>0.05).(3)There was a statistically significant difference in the average heart rate and ventricular wall activation time(VAT V6)levels between the two groups of patients(P<0.05);There was no statistically significant difference in ventricular wall activation time(VAT V1)(P>0.05).(4)The level of GDF15 in the CSF group was significantly higher than that in the normal group(P<0.05);There was no significant difference in PTX3 levels between the two groups of patients(P>0.05).(5)Unconditional logistic regression analysis showed that TG,low HDL-C,hs CRP,VAT v6,and GDF15 were independent risk factors for CSF.(6)The coronary artery corrected TIMI frame count(CTFC)in the CSF group was positively correlated with GDF15(r=0.745,P=0.00).(7)ROC curve analysis shows that the optimal cutoff value of GDF15 for CSF is 1285,the area under the curve is 0.890,and the sensitivity and specificity are 67.5%and 75.1%,respectively.Conclusion:This study shows that1.TG,low HDL-C,hs CRP,VAT v6,and GDF15 are independent risk factors for CSF.2.There is a significant correlation between GDF15 and slow coronary flow;The diagnosis of CSF has certain value.3.PTX3 is not correlated with CSF and cannot be used for the diagnosis of CSF.