Analysis Of Clinical Characteristics And Risk Factors Of Lupus Nephritis Combined With Atherosclerosis

Objective(s):The risk of cardiovascular events in systemic lupus erythematosus(SLE)is higher,and the risk of lupus nephritis(LN)combined with atherosclerosis is higher than that of SLE patients who do not merge LN.This study collects data on LN patients in our hospital,analyzes their general clinical data,laboratory data,immunological indicators,medication status,and pathological types,and analyzes them to discover the risk factors of LN combined with AS,and provides a certain clinical basis for early clinical intervention.Methods:In this study,a total of 216 cases of LN patients who visited our hospital from January2019 to October 2022 were collected.All patients met the SLE classification criteria revised by the American Rheumatology Association in 1997,and at the same time met the diagnostic criteria of LN.Kidney biopsy examination of 127 cases,and carotid artery color ultrasound was performed by a fixed physician.Collect clinical data of patients,activity scores of systemic lupus erythematosus disease,and the use of glucocorticoids and immunosuppressants;laboratory data include: biochemical data and related antibodies.Adopting the 2017 consensus on the diagnosis and treatment of head and neck atherosclerosis in China: Both sides of the common carotid artery IMT is less than1.0mm is considered normal and included in the non-merged AS group.c IMT≥1.0mm on either side is defined as thickening of the carotid artery and included in the combined AS group.Statistical methods were used to analyze the above indicators,and the factors that were more statistically significant(P<0.05)between the groups were included in the multi-factor logical regression model to obtain independent risk factors.Results:In this study,a total of 216 patients with lupus nephritis,87 patients with combined AS,14 patients with LN <20 years old,and 1 patient with combined AS were collected.Patients aged 20-30 with combined AS accounted for 1.9%,31-40 years old accounted for16.7%,41-50 years old with combined AS accounted for 54.7%,49 patients over 50 years old,48 cases were detected with combined AS,and the incidence of AS increased with age.The age of the LN-merged AS group was significantly higher than that of the LNmerged AS group(P<0.01),the incidence of CKD in the LN-merged AS group was higher than that of the LN-merged AS group(P<0.05),the incidence of hypertension and diabetes in the LN-merged AS group was significantly higher than that of the LNmerged AS group(P<0.01),the systolic blood pressure in the LN-merged AS group was significantly higher than that of the LN-merged AS group(P<0.01),and the course of the LN-merged AS group was significantly longer than that of the LN-merged AS group(P<0.01).),the BMI of the LN merged AS group is higher than that of the LN merged AS group(P<0.05),and the CRP value of the LN merged AS group is higher than that of the LN merged AS group(P<0.05).There was a difference in the use of glucocorticoids between the LN combined AS group and the LN non-combined AS group(P<0.01),suggesting that the use of glucocorticoids was related to the combined AS.Conclusion(s):1.The incidence of LN combined with AS increases with age and course of the disease.2.Age,course of disease,BMI,hypertension,diabetes,abnormally elevated CRP,CKD and glucocorticoid dose are related to LN combined with AS.3.Age and course of disease are independent risk factors for LN combined with AS.