Clinial Significance Of Cerebral Injury Markers GFAP And UCH-L1 In The Diagnosis And Severity Assessment Of Acute Ischemic Stroke

Objective: To investigate the expression of serum glial fibrillary acidic protein(GFAP),ubiquitin C-terminal hydrolase L1(UCH-L1),markers of brain injury,in the early stage of acute ischemic stroke(AIS),and to explore the correlation between GFAP,UCH-L1 and clincal diagnosis of AIS.Methods:Collect datas from the Fourth Ethics Committed affiliated to China Medical University from March 2022 to September 2022.The 42 patients with acute ischemic stroke within 24 hours after the onset of hospitalization in the Neurology who had improved the detection of serum GFAP,UCH-L1 and magnetic resonance angiography(MRA)were taken as the research objects,and were included in the experimental group,and the other 20 health examinees were selected as the control group.Collect general clinical data,serum GFAP,UCH-L1 of the study subjects,and compare the differences in serum GFAP,UCH-L1 between different groups;Draw Receiver operating characteristic to evaluate the diagnostic value of GFAP,UCH-L1 in acute ischemic stroke.The internal blood vessels of patients with acute ischemic stroke were analyzed by magnetic resonance angiography(MRA).The patients with acute ischemic stroke were divided into two subgroups,namely,Great vessels occlusion group and small vessel occlusion group.The expression of serum GFAP and UCH-L1 at different time points between the two subgroups were compared to observe whether there were statistical differences;Using the National Institute of Health Stroke Scale(NIHSS),acute ischemic stroke patiences were evaluated for NIHSS scores,and serum GFAP and UCH-L1 were analyzed at different time points.Results:1.The median levels of serum GFAP and UCH-L1 in the experiment group were significantly higher than those in the control group within 24 hours of onset,with statistical significence(P<0.05).2.Drawing Receiver operating characteristic,we found that the sensitivity of serum GFAP level in diagnosing acute ischemic stroke was 66.7%,and the specificity was100%;the sensitivity of serum UCH-L1 level in diagnosing acute ischemic stroke was71.8%,and the specificity was 75%;3.Compared with the subype groups of acute ischemic patients,the serum GFAP and UCH-L1 indicators in the great vessel occulusion group were higher than those in the small vessel occlusion group at the onset of 24 hours,with statistical significence(P<0.05).4.The serum GFAP and UCH-L1 indicators in patients with acute ischemic stroke within24 hours of onset were positively correlated with NIHSS score,indicating that the higher the serum GFAP and UCH-L1 indicators,the higher the NIHSS score,and had statistical sihnificance(P<0.05).Conclusion:1.The serum GFAP and UCH-L1 indicators in patients with acute ischemic stroke within 24 hours of onset are higher than those in the normal population.2.The sentivity and specificity of serum GFAP and UCH-L1 levels in diagnosing acute ischemic stroke within 24 hours of onset are high;3.The increase of serum GFAP and UCH-L1 valuesin patients with acute ischemic stroke within 24 hours after onset may indicate that the pathogensis is great vessels occlusion.4.The higher the serum GFAP and UCH-L1 values in patients with acute ischemic stroke within 24 hours of onset,the more severe neurological dificits is indicated.5.Serum GFAP and UCH-L1 play an important role as serum markers in diagnosing acute ischemic stroke and evaluating its severity.