| Objective:Using synchronous electroencephalogram-magnetic resonance spectroscopic technology(EEG-MRS),to explore the difference of GABA+/Glx(GABA/glutamate-glutamine)ratio in prefrontal lobe under non rapid eye movement(NREM)sleep between patients with narcolepsy type 1(NT1)and normal control group,and to explore the correlation between this difference and abnormal cognitive function.Methods:We obtained MRS measures of GABA+and Glx concentrations as well as synchronous EEG data from 20 patients with NT1 and 20 sex-and age-matched healthy community volunteers.We used the Beijing version of the Montreal Cognitive Assessment(MoCA)to appraise their cognition,and the Epworth Sleepiness Score(ESS)to measure daytime sleepiness.All subjects performed an overnight polysomnography map(PSG)the night before MRS scanning to study and calculate their sleep stages.Statistical analysis involved the assessment of patient-control group differences in the individual measures of GABA+and Glx,as well as in the ratio of the GABA+to Glx measures.Additionally,we explored whether the differences were related to their cognition.Results:The GABA+/Glx ratio of patients with narcolepsy was higher than the normal control group(P=0.0002),the GABA+level was higher than the control group(P=0.0062),while there was no significant difference in Glx level(P=0.6699).And the correlation analysis showed that the GABA+/Glx ratio was negatively related to their abnormal cognitive function(r_s=-0.7453,P=0.0002).Moreover,GABA+level was inversely proportional to the rapid eye movement sleep latency(REML)in patients with narcolepsy(r_s=-0.6917,P<0.01).Conclusion:This study found that the proportion of GABA+/Glx in prefrontal lobe of NT1 patients during N2 sleep was higher than that of normal control group which mainly caused by GABA+,and the ratio was negatively related to their abnormal cognitive function.The data also showed that the GABA+level was inversely proportional to the REML. |
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