Clinical Significance Of Serum IgE Level In Aged Patients With Tumor

Objective:Immunoglobulin E(IgE)is a secreted immunoglobulin that is mainly involved in inducing type I allergic reactions.In clinical observation,it was found that the serum IgE levels in elderly patients with malignant tumors have an upward trend,but the clinical significance of the increase is currently unclear.This study aims to analyze the changes in serum IgE levels in elderly patients with malignant tumors,clarify whether IgE levels are related to the incidence of tumors in elderly patients,and further explore the clinical significance of changes in serum IgE levels in elderly patients with malignant tumors.Method:Collect and organize 234 elderly malignant tumor patients who have been hospitalized in the geriatric department of a tertiary hospital in the past 10 years and diagnosed with malignant tumors through pathological diagnosis,and have also completed serum IgE testing as the research subjects.Excluding allergic constitution,asthma history,and allergic history,215 elderly patients with non malignant tumors in the same hospital were used as the control group.Compare the serum IgE levels among the elderly malignant tumor group,control group,and different pathological types and tissue types of elderly malignant tumors using independent sample t-test.Using chi square test and logistic regression analysis methods to analyze the influencing factors of malignant tumor risk in elderly patients.Result:1.The average serum IgE of elderly tumor patients(231.77 ± 341.29 IU/ml)was significantly higher than that of the control group(73.82 ± 75.88 IU/ml)(P<0.01);Moreover,the average serum IgE values of elderly patients with lung cancer and elderly patients with gastrointestinal malignancies(colorectal,gastric,hepatobiliary,pancreatic cancer)were significantly higher than those of the control group;The average serum IgE value of elderly lung cancer patients was significantly higher than that of elderly gastrointestinal cancer patients(P<0.05).2.In the elderly lung cancer group,there was a statistically significant difference in the average serum IgE levels among the three groups of adenocarcinoma,squamous cell carcinoma,and small cell carcinoma.The serum IgE levels in adenocarcinoma patients were the most significantly increased(331.07 ± 452.65 IU/ml),followed by small cell carcinoma(246.47 ± 297.78 IU/ml)and squamous cell carcinoma(150.04 ± 178.57IU/ml)(P<0.05);In elderly patients with gastrointestinal malignant tumors,there was no statistically significant difference in the average serum IgE values among the three groups: gastric cancer(148.72 ± 195.97 IU/ml),colorectal cancer(172.76 ± 217.69IU/ml),and hepatobiliary pancreatic cancer(150.85 ± 185.35 IU/ml),and there was no difference between any two groups(P>0.05).3.The logistic regression analysis of risk factors for elderly patients with malignant tumors showed that after adjusting for confounding factors,age and serum IgE levels were independent influencing factors for the occurrence of malignant tumors in elderly patients(P<0.01);≥ Compared with the elderly population aged 60-64,the 65 year old population has an increased risk of developing malignant tumors(OR=4.711,95%CI=2.958-7.505,P<0.01);The elderly population with IgE>100 IU/ml has an increased risk of developing malignant tumors compared to the elderly population with IgE ≤100 IU/ml(OR=2.982,95% CI=1.947-4.566,P<0.01).4.In the elderly population,there is a significant difference in the incidence of malignant tumors among the three groups: the normal IgE group(<25 IU/ml),the critically elevated IgE group(25-100 IU/ml),and the elevated IgE group(>100 IU/ml)(x~2=33.367,P<0.01)。 The incidence of malignant tumors in the IgE elevated group was significantly higher than that in the IgE normal group(P<0.05)and the IgE critical elevated group(P<0.05).5.In the elderly population,the group with elevated IgE(>100 IU/ml)had an increased risk of developing lung cancer compared to the group with normal IgE(<25 IU/ml)(OR=3.385,95% CI=1.828-6.269,P<0.01),among which the risk of developing lung adenocarcinoma was significantly increased(OR=4.570,95% CI=2.131-9.803,P<0.01);For malignant tumors of the digestive tract,especially liver,gallbladder,and pancreatic cancer,the risk of cancer in populations with a critical increase in IgE(25-100 IU/ml)is actually reduced(OR=0.178,95% CI=0.034-0.926,P<0.05).Conclusion: The serum IgE levels in elderly patients with malignant tumors are significantly elevated.In elderly lung cancer patients,there is a correlation between serum IgE levels of different pathological types,with the most significant increase in serum IgE in lung adenocarcinoma patients,followed by small cell carcinoma and squamous cell carcinoma of the lung.The serum IgE level is positively correlated with the risk of malignant tumors in the elderly population,and the risk of malignant tumors is significantly increased in elderly populations with elevated serum IgE levels(>100IU/ml).The serum IgE level has certain clinical significance for the diagnosis of elderly malignant tumors and may become one of the important clinical indicators for predicting different pathological types of tumors.