Study Of Glucose And Lipid Metabolism,Coagulation-Related Indicators And Persistent HPV Infection

Objective: The correlation between glucolipid metabolism and coagulation-related indicators and persistent HPV infection was clarified by collecting and analyzing the relationship between glucolipid metabolism and coagulation-related indicators and persistent HPV test results.Methods: A total of 1000 patients were selected to complete human papillomavirus and cervical fluid-based cytology examinations at the First Affiliated Hospital of Xinjiang Medical University from January to December 2021,and the correlation between persistent human papillomavirus infection and glycolipid metabolism and coagulation-related indicators were studied and analyzed for predictive value according to inclusion and exclusion criteria.Results: Body mass index,systolic blood pressure,diastolic blood pressure,triglycerides,and fibrinogen were all lower in HPV-positive patients than in HPV-negative patients,and the differences were statistically significant(P<0.05);activated partial thromboplastin time,glycated hemoglobin,and high-density lipoprotein were all higher in HPV-positive patients than in HPV-negative patients,and the differences were statistically significant(P<0.05).Glycated hemoglobin was higher in patients with multiple HPV infections than in patients with single HPV infections,with a statistically significant difference(P<0.05);glycated hemoglobin,triglycerides,total cholesterol,fibrinogen,and albumin were higher in patients with persistent HPV infections than in patients with HPV infection transitions,and the difference was statistically significant(P<0.05);The results of multi-factor logistic analysis showed that glycosylated hemoglobin,triglycerides,fibrinogen and albumin were risk factors for persistent HPV infection;The AUCs of glycated hemoglobin,triglyceride,fibrinogen,and albumin alone and in combination were 0.591,0.626,0.593,0.597,and0.722,The predictive efficacy of the combination of the four indicators in predicting persistent HPV infection was higher than that of each value alone,with a sensitivity of82.1% and specificity of 52.5%.Conclusion: Persistent human papillomavirus infection is associated with glycolipid metabolism and coagulation-related indicators,The combination of glycated hemoglobin,triglycerides,fibrinogen,and albumin is more predictive of persistent human papillomavirus infection.