Comparison Of Propofol And Sevoflurane On Perioperative Sleep In Frail Tumor Patients

Objective: The aim of this study is to investigate the effect of propofol or sevoflurane maintenance anaesthesia guided by Bispectral Index(BIS)on perioperative sleep and pain indicators in patients with debilitating tumours,with a view to providing a clinical basis for perioperative refinement.Methods: This study prospectively included patients with debilitating tumors who were to be treated surgically at the Affiliated Cancer Hospital of Xinjiang Medical University from 02/2022 to 02/2023.Patients were assigned to the propofol group(P group,n=38)and the sevoflurane group(S group,n=38)according to a computer-generated random number sequence in a 1:1 ratio,and the two groups were collected for preoperative and postoperative sleep,intraoperative vital signs,postoperative pain management,and other information for comparison.Results: 1.Patients in group P had lower PSQI scores and AIS scores than group S within seven days after surgery.The difference in the incidence of postoperative sleep disturbance based on PSQI scores between the two groups was statistically significant on postoperative day 1(P <0.05);the difference in the incidence of postoperative sleep disturbance based on AIS scores was statistically significant on postoperative days 3 and 7(P < 0.05).2.There was a statistically significant difference in the duration of intraoperative hypotension and hypertension between the two groups(P < 0.05).3.There was no statistically significant difference in the length of postoperative resuscitation and the length of extubation between the two groups(P > 0.05).4.There was no statistically significant difference between the two groups in terms of pain VAS scores within 7 days after surgery(P >0.05).Conclusion:1.The use of intravenous propofol during maintenance anaesthesia was more advantageous than sevoflurane inhalation in protecting postoperative sleep quality in patients with debilitating tumours.2.The use of sevoflurane during maintenance anaesthesia is superior to propofol in maintaining haemodynamic stability in patients with debilitating tumours.3.No differential effects of BIS-guided propofol or sevoflurane maintenance anaesthesia were seen on the length of postoperative resuscitation,length of extubation and postoperative cognitive function in patients with debilitating tumours.