| Objective: To analyze the clinical characteristics of different types of juvenile idiopathic arthritis,and to explore the risk factors related to the relapse of juvenile idiopathic arthritis.Methods: The clinical data of 101 children with JIA admitted to the pediatric Department of the First Affiliated Hospital of Xinjiang Medical University from July 2020 to July 2022 were included,and the clinical characteristics of each subtype were analyzed.In addition,the above children were grouped according to the recurrence of the disease during treatment,among which 27 cases in the recurrence group were classified as the recurrence group.74 cases without recurrence were classified as non-recurrence group.The differences in baseline data,drug discontinuation during treatment,and adjusted medication between the two groups were compared.The risk factors for disease recurrence in children with JIA 6 months after initial treatment were analyzed.SPSS26.0software was used for statistical analysis,and statistical data were compared by T-test or rank sum test,chi-square test or Fisher exact probability method.Multivariate Logistic regression analysis identified independent risk factors for JIA recurrence.Results:Multiarticular(RF-)JIA accounted for the majority of cases,41 cases(40.59%).The most common clinical symptom was joint pain.The children in p JIA(RF+)group showed more limited joint movement than those in ERA.Compared with children with other types of JIA,s JIA is more prone to autoinflammatory disease manifestations.In the analysis of risk factors for disease recurrence in children with JIA,univariate analysis showed differences in the distribution of fever,rash,hemoglobin,TNF-α,neutrophil count,positive ESR,RF,anti-CCP antibody,sacroiliac joint involvement,and drug withdrawal between the two groups.Multivariate Logistic regression analysis showed that rapid ESR,sacroiliac joint involvement,positive anti-CCP antibody and drug withdrawal were independent risk factors for disease recurrence,while initial treatment with biological agents was protective factor.Conclusions: Multi-articular(RF-)JIA was the most common type,and the top three joints most involved were the knee joint(62.4%),ankle joint(47.5%),and sacroiliac joint(44.6%).Rapid ESR,sacroiliac joint involvement,positive anti-CCP antibody,and drug withdrawal are independent risk factors for relapse of JIA,and initial treatment with biological agents is a protective factor,suggesting that early and persistent use of biological agents should improve prognosis.Conclusions: 1.Multi-articular(RF-)JIA was the most common type,and the top three joints most involved were the knee joint(62.4%),ankle joint(47.5%),and sacroiliac joint(44.6%).Rapid ESR,sacroiliac joint involvement,and positive anti-CCP antibody are independent risk factors for JIA recurrence,and early and persistent use of biological agents should be used to improve prognosis. |
