Correlation Of Retrobulbar Blood Flow With Retinal Nerve Fiber Layer And Choroid In Primary Angle-Closure Glaucoma

Objective:To investigate the correlation between retrobulbous blood flow and retinal nerve fiber layer and choroid in angle-closure primary glaucoma.Methods:This is a prospective study.38 patients with primary angle-closure glaucoma in 76 eyes and 27 controls in 54 eyes were included in this study.EDI-OCT measured the choroidal thickness(CT)below,nasal,temporal,above,and below the central macular recess at 1mm and 3mm from the central macular recess,and OCT measured the nerve fiber layer thickness above,below,nasal,and temporal aspects of the optic disc(RNFL).Color Doppler ultrasound measured the peak systolic flow velocity(PSV),end-diastolic flow velocity(EDV),and resistance index(RI)of the ophthalmic artery(OA),central retinal artery(CRA),and posterior ciliary artery(PCA).Statistical analysis was performed to correlate the retrobulbar flow parameters with RNFL and CT in the glaucoma group.Results:The RNFL of the glaucoma group were lower than the control group,the CT were higher than the control group,and the EDV of CRA and the PSV and EDV of PCA were lower than the control group.The superior,inferior,and nasal RNFL of optic disc were negatively correlated with the RI of PCA,respectively;the nasal RNFL was positively correlated with the EDV of OA and negatively correlated with the RI;the temporal RNFL was positively correlated with the EDV of OA.PSV of CRA was negatively correlated with CT at N3 mm,T3mm,S3 mm,I1mm,and I3 mm,EDV was negatively correlated with CT at SFCT,T3 mm,and I3 mm,and RI was positively correlated with CT at I3mm;EDV of OA was negatively correlated with CT at I1 mm,and RI was positively correlated with CT at N1 mm.The EDV of OA was negatively correlated with CT at I1 mm and RI was positively correlated with CT at N1mm;the EDV of PCA was negatively correlated with CT at I3 mm.CT thickening at N1 mm is a risk factor for glaucoma.Conclusion:In glaucoma group,the choroid thickened,the retrobulbar blood flow velocity slowed down,and the RNFL became thinner.