| Objective: High altitude environment affects the attentional function of migrant population,but the physiological mechanism of red blood cells behind it is still unclear.In this study,we collected the physiological indexes of red blood system,used the attentional network test task,combined with the brain network analysis method to observe the changes of long-term hypoxia exposure on the structure and function of red blood cells,and explored the neurophysiological mechanism behind the changes of attentional function,expecting to provide the theoretical basis and experimental basis for the prevention and treatment of cognitive impairment in high altitude.It also provides theoretical support for how to protect the cognitive function of residents in high-altitude environment and predict individual plateau adaptation,and provides a reasonable basis for the formulation of corresponding national policies on aid to Tibet and retirement.Methods: The subjects of this study were university students who had moved to a high altitude area for more than one year.The first part combined with the attentional network test task to identify red blood cell indicators that were closely associated with behavioral indicators of attentional function.In the second part,participants were divided into a normal group and a high blood cell group according to whether the erythrocyte index was outside the normal clinical reference range.By comparing the results of the differences in brain networks between the two groups,the effects of erythrocyte oxygen transport function on the attention network function and neurophysiological mechanisms of individuals moving to high altitude were investigated.Results: The first part of the results showed that two indicators,hemoglobin concentration and mean hemoglobin content in eight erythrocytes,were higher than the normal medical reference range.Further combined with the behavioral performance of the attentional network,it was found that there were significant differences in the attentional alertness network between groups under both indicators;there was no significant correlation between hemoglobin concentration and the scores of the three sub-networks of attention,while there was a significant negative correlation between mean hemoglobin content and the attentional alertness network,and the regression analysis found that mean hemoglobin content could predict the alertness network to some extent,thus determining that mean hemoglobin content The regression analysis found that the mean hemoglobin content could predict the vigilance network to a certain extent,thus determining that the mean hemoglobin content was closely associated with attentional functional behavior.The second part of the results based on EEG task state network connectivity showed that the normal group had weaker network connectivity in the brain regions corresponding to vigilance and executive control relative to the high group,and enhanced network connectivity in the brain regions corresponding to orientation in the normal group relative to the high group.The results of differences in network topological properties showed that both alert and executive control networks showed lower clustering coefficients,global efficiency,and local efficiency in the healthy group than in the high group,and longer characteristic path lengths in the healthy group than in the high group.Also the clustering coefficients and local efficiencies in the alert response time and its corresponding network attributes showed significant negative correlation. |
