| ObjectiveBy analyzing the clinical data of newly diagnosed patients with systemic lupus erythematosus(SLE)in our hospital,the relationship between the fibrinogen-albumin ratio(FAR)and disease activity and lupus nephritis in patients with newly diagnosed SLE was explored.MethodsThe clinical data of 156 newly diagnosed SLE patients were analyzed by cross-sectional analysis,such as C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),complement(C),FAR,systemic lupus erythematosus disease activity index(SLEDAI),etc.159 healthy people were included as control group.SLE patients were divided into mild disease activity group(SLEDAI<10)and moderate to severe disease activity group(SLEDAI≥10)according to the internationally accepted SLEDAI-2000(SLEDAI-2000).According to the presence or absence of lupus nephritis,the patients were divided into lupus nephritis group(LN group)and non-lupus nephritis group(NLN group).The differences in FAR between the groups were analyzed.Spearman/Pearson correlation analysis was used to explore the correlation between FAR and laboratory indicators and SLEDAI score in SLE patients.Binary Logistic regression model was used to analyze the risk factors for moderate to severe activity and lupus nephritis in SLE.Receiver operating characteristic(ROC)curve was used to evaluate the value of FAR in predicting SLE,the activity of SLE and LN.Results(1)The FAR of SLE patients was significantly higher than that of healthy controls(Z=-10.390,P<0.001).The FAR of SLE patients in the moderate and severe disease activity group was higher than that in the mild disease activity group(Z=-4.703,P<0.001).The FAR in lupus nephritis group was significantly higher than that in non-lupus nephritis group(Z=-6.312,P<0.001).(2)The FAR of SLE patients was negatively correlated with C3(r=-0.249,P=0.002),serum protein(r=-0.474,P<0.001),and positively correlated with ESR(r=0.383,P<0.001),CRP(r=0.293,P<0.001),blood urea nitrogen(r=0.220,P=0.006),uric acid(r=0.296,P<0.001),creatinine(r=0.180,P=0.025),24-hour urine protein(r=0.588,P<0.001)and SLEDAI(r=0.430,P<0.001).(3)Binary Logistic regression analysis showed that FAR was an independent risk factor for moderate to severe activity and lupus nephritis in SLE.(4)According to ROC curve,the area under the curve of FAR for predicting SLE was 0.839(95%CI: 0.793～0.884),the sensitivity was 71.2%,and the specificity was 84.9%.The area under the curve for predicting moderate to severe SLE activity was 0.718(95%CI: 0.637～0.799),the sensitivity was 73.2%,and the specificity was 63.5%.The area under the curve for predicting lupus nephritis was 0.795(95%CI: 0.723～0.867),the sensitivity was 63.2%,and the specificity was 83.0%.ConclusionsLupus nephritis(LN)was detected in 43.6% of newly diagnosed SLE patients.Fibrinogen-albumin ratio is an independent risk factor for moderate to severe disease activity and lupus nephritis in patients with newly diagnosed systemic lupus erythematosus.In addition,the ratio of fibrinogen to albumin has a good predictive value for the occurrence,disease activity and lupus nephritis of systemic lupus erythematosus. |
