Cerebral Small Vessel Disease Total Load And Carotid Intima-media Thickness In Patients With Ischaemic Stroke Correlation Study

Objective:To analyze and count the imaging manifestations of cerebral small vessel disease(CSVD)in 193 ischemic stroke patients using a GE 3.0T nuclear magnetic resonance imaging(MRI)scanner,to investigate the correlation between the total CSVD load and its different subtypes and carotid intima-media thickness(c IMT),and to analyze the risk factors for the total CSVD load.To investigate the correlation between total CSVD load and its subtypes and carotid intima-media thickness(c IMT),and to analyse the risk factors for total CSVD load.Methods:One hundred and ninety-three patients with ischemic stroke who visited our hospital(Chengde Central Hospital)for outpatient and inpatient neurological surgery between September 2021 and May 2022 were included.All patients were admitted to the hospital for cranial MRI(T1WI,T2 WI,FLAIR,DWI,and SWI sequences were completed in all patients)and cervical vascular ultrasound.According to the MRI imaging results,the total CSVD load was scored and grouped according to the location and severity of each subtype of CSVD,and the patients were statistically analysed for differences in c IMT between the groups.Their clinical data were also analysed in detail,including gender,age,history of smoking,history of alcohol consumption,previous history(hypertension,diabetes,coronary artery disease,hypercholesterolaemia),and independent risk factors for increased CSVD total load score were analysed.The study was analysed and statistically validated using SPSS 23.0 software,using chi-square tests,non-parametric tests,multi-factor logistic regression analysis,one-way ANOVA tests and post-hoc multiple comparison analysis,with results significant at P<0.05.Results:1.Of the 193 patients enrolled,139 were male and 54 were female,with a median age of 64.0±11.0 years and a c IMT range of 0-1.4 mm,mean0.821 ± 0.329 mm.hypertension and age were independent risk factors affecting the CSVD total load score.c IMT was compared between the five groups of patients with different CSVD total load scores,and the differences were statistically significant(p<0.05).The differences were statistically significant(P < 0.05)and the c IMT values increased with the severity of CSVD total load.2.In the different groups of WMH and EPVS,there was a significant difference in c IMT values between the groups(p<0.0.5).c IMT values increased with the worsening of WMH and EPVS.3.The difference in c IMT between patients without CMBs and those with CMBs was statistically significant(P < 0.05).There was a significant difference in c IMT between patients in the basal/thalamic,subcurtain and cortical/subcortical groups(P=0.001,0.003),and no significant difference between the other groups(P>0.05).4.Statistical analysis was performed between LI groups and the mean c IMT values varied between groups,but there was no statistically significant c IMT for patients between groups(p=0.648).Conclusions:1.The more severe the total CSVD load,the thicker the c IMT in patients with ischaemic stroke,suggesting that the condition and severity of CSVD can be predicted by c IMT thickening,which may reduce the occurrence of future cerebrovascular disease.2.Among the different subtypes of CSVD,WMH,EPVS classification,and CMBs in deep brain regions have a strong correlation with c IMT,whereas LI has little effect on c IMT.3.Age and hypertension were independent risk factors for elevated total load scores in CSVD patients.