Clinical Characteristics Of Non Hepatitis B Virus Associated Hepatocellular Carcinoma

Objective:This study retrospectively analyzed the difference of clinical characteristics between non hepatitis B B virus related HCC patients and hepatitis B virus related HCC patients,providing reference value for exploring the prevention,treatment and prognosis of non hepatitis B virus HCC.Methods:Through retrospective analysis,we studied the case data of patients with liver cancer admitted to the Department of Hepatobiliary Surgery of the Affiliated Hospital of Youjiang Medical University For Nationalities from January 2019 to March 2022.Patients can be divided into hepatitis B negative group(group A)and hepatitis B positive group(group B)according to the results of five quantitative tests of hepatitis B in serum upon admission.Collect basic clinical information about the patient,including gender,age,health status,and possible diseases.General information about the tumor was collected,including its size,number,whether it had lymph node or intrahepatic metastasis,and whether it had distant metastasis.Tumor indicators,including CA99,CA53,and AJCC grading data.At the same time,patients were divided into HBV negative operation group(A1 group),HBV negative TACE group(A2 group),HBV positive operation group(B1 group)and HBV positive TACE group(B2 group)according to the difference of hepatitis B virus infection and surgical methods.Preoperative and postoperative laboratory data were collected respectively.Preoperative and postoperative AST,ALT,AFP,albumin,and liver function grading were included.At the same time,intraoperative vascular infiltration and postoperative pathological indicators of the operation group were collected,namely,intraoperative and pathological data of group A1 and B1,including intraoperative vascular infiltration,Arg-1,CD34,pathological grading,MVI grading and other data.Results:A total of 138 patients were included in this study,including 38 patients in group A with an average age of(54.27 ± 12.77)years,and 100 patients in group B with an average age of(51.26±11.14)years.There is a significant difference in the sex ratio between A group and B group,the former has 28 males,the latter has 10 females,and the latter has 88 males and 12 females.The statistical analysis results show that the difference is significant(P<0.05).There were 13 patients with cirrhosis in group A and 82 patients with cirrhosis in group B.There was significant difference in the proportion of cirrhosis between the two groups(P<0.05).There was no significant statistical difference between A and B groups in the basic clinical information of the patients observed,including gender,age,health status and the prevalence of diabetes(P>0.05).In terms of AJCC grading of tumor,this paper only analyzed the tumor and found that there was significant statistical difference between A group and B group in tumor grading(P<0.05),but there was no statistical difference in AJCC grading.In terms of general conditions and indicators of tumor,this study found that there was no significant statistical difference between group A and group B in tumor diameter,distant metastasis,lymph node metastasis and CA99 and CA53 levels(P>0.05).At the same time,according to the different surgical methods selected by the patients after admission,the patients who met the inclusion criteria were divided into four groups:hepatitis B virus negative surgery group(A1 group),hepatitis B virus negative TACE group(A2 group),hepatitis B virus positive surgery group(B1 group),and hepatitis B virus positive TACE group(B2 group).In all the cases selected for surgery,this study found that there was significant statistical difference between group A1 and group B1 in liver function grading after surgery(P<0.05).However,there was no significant difference in preoperative liver function,preoperative and postoperative AST,ALT,AFP,albumin and total bilirubin(P>0.05).Among all the patients who chose TACE,there was significant statistical difference in ALT between group A2 and group B2(P<0.05).There was no significant difference between the two groups in preoperative AST,preoperative and postoperative ALT,AFP,albumin,total bilirubin and preoperative liver function grading(P>0.05).Compared with the postoperative pathology and vascular infiltration in group A1 and B1,there was significant statistical difference in Arg-1 and CD34 between the two groups(P<0.05).There was no significant difference in vascular infiltration,postoperative pathological grade and MVI grade(P>0.05).Conclusions:1.There is a difference in the sex ratio between non hepatitis B virus related HCC patients and hepatitis B virus related HCC patients,and the proportion of men and women in non hepatitis B virus related HCC patients is higher than that in hepatitis B virus related HCC patients.2.The incidence rate of cirrhosis in patients with non hepatitis B B virus related HCC is lower than that in patients with hepatitis B virus related HCC,and this difference may affect their health status.3.AFP is also applicable to the diagnosis of non hepatitis B virus related HCC patients,and the judgment of tumor recurrence and prognosis after surgery.4.Non hepatitis B virus related HCC is less likely to have intrahepatic infiltration than hepatitis B virus related HCC.