| Objective:1.Analyze and summarize the current situation of abnormal detection of thyroid function and antibodies among employees of a tertiary hospital in Yan’an City;2.Analyze whether there are differences in the detection of thyroid antibody abnormalities in gender,age,BMI,relevant laboratory indicators,and occupation,to provide certain health guidance for the prevention and treatment of thyroid diseases of staff in our hospital,and also provide reference for the prevention of thyroid diseases among employees in other hospitals.Method:1.The analysis of laboratory indicators related to thyroid and physical examination of staff in our hospital adopts the cross-sectional study method to collect the complete data of 1789 staff who completed physical examination in the Affiliated Hospital of Yan’an University and the Cardiovascular and Cerebrovascular Branch from June 1,2021 to June 1,2022.According to the admission and discharge criteria,collect the basic data,clinical biochemical indicators and departments of employees,including gender,age,blood pressure(BP,systolic and diastolic blood pressure),height,body mass,body mass index(BMI),thyroid function(TSH,T3,T4,FT3,FT4),Thyroid antibodies(TPOAb and TGAb),fasting plasma glucose(FPG),blood lipids(TG and LDL),blood routine: red blood cell count(RBC),white blood cell count(WBC),hemoglobin content(Hb),red blood cell volume(HCT),etc.2.Analyze the general characteristics of the above data,count the number of abnormal TSH,T3,T4,FT3 and FT4 according to the detection of thyroid hormone,and calculate the detection rate of abnormal TSH,T3,T4,FT3 and FT4;3.According to the detection of thyroid antibodies,count the normal and abnormal number of TGAb and TPOAb,calculate their abnormal detection rate,divide thyroid antibodies into normal group and abnormal group,compare the general information of the study object,clinical biochemical indicators and the impact of the department on thyroid antibodies,and use Excel2022 for data collection and SPSS26.0 data software for statistical analysis.Result:1.Analysis of basic data characteristics of 1789 employees undergoing physical examination(1)Basic information of the study subjects: A total of 1789 cases were identified,and the number of women was significantly higher than that of men(72.7%/27.3%).The age range is between 21～59 years old,and the average age is 38.18±7.67 years old;Mainly employees aged 30～40,with 1033 cases(57.7%);The departments of this hospital are divided into clinical departments,medical technology departments,and administrative logistics departments according to their functions.The number of clinical departments is the highest,with 1117 cases,accounting for 62.4%.(2)Detection of thyroid hormones and antibodies: The results of this study showed that the detection rate of thyroid antibody abnormalities in 1789 subjects was significantly higher than that of thyroid hormone abnormalities(23.6% / 12.3%).The largest number of abnormal TSH in thyroid hormones was 153(8.5%).The overall abnormal detection rate of TPOAb in antibodies was higher than that of TGAb(18.4%/14.4%),and the abnormal thyroid antibody detection in female was higher than that in male(25.7% / 18.0%).The results of the analysis of thyroid antibody abnormalities in different age groups showed that the detection rate of abnormal antibodies was basically the same in the age groups of 20～30 years old,30～40 years old and 40～50 years old,and the age group of 50～60 years was higher than that of other age groups.2.Basic factors affecting thyroid antibodies(1)The total detection rate of thyroid antibody abnormalities was 23.6%,the prevalence between sexes was 25.7% in women and 18.0% in men,and the difference between the detection rates of abnormal thyroid antibodies in women and men was statistically significant(X~22 value = 11.678,P = 0.000).(2)There was no significant difference in the detection rate of thyroid antibody abnormalities in each age group(20～30 years old,30～40 years old,40～50 years old and50～60 years old)(24.6%,22.4%,23.8%,28.7%,respectively)(X~22 value = 3.974,P =0.264).(3)According to BMI(<18.5,18.5～24.0,24.0～28.0 and ≥28.0),they were divided into malnutrition group,normal weight group,hyperplasia group and obesity group,respectively.And deviations of thyroid antibodies(27.0%,23.9%,23.8%,14.3%)were insignificant and BMI classification(X~22 value=4.676,P =0.197).(4)The study subjects were divided into normal thyroid antibody group and abnormal group according to whether thyroid antibodies were normal,the differences between indexes and thyroid antibodies between different biochemical indexes TSH,T3,FT4,FT3,RBC,HB,TG,LDL were statistically significant(P <0.05),The differences were statistically significant(P <0.05),while systolic blood pressure,diastolic blood pressure,BMI,FBG,WBC,and HCT factors(P >0.05).According to whether TSH was normal,the results showed that abnormal TSH group was much higher than the normal TSH group(47.1% / 21.4%),and the thyroid antibodies in both groups were statistically significant.(P <0.05).(5)The detection rate of thyroid antibody abnormalities is the highest in the ruling logistics department,accounting for 23.6%(267 cases),while the medical technology department has the lowest detection rate,59 cases(22.1%).Clinical departments were in between,accounting for 23.9%(267 cases).The difference was not significant between the department where the staff of our hospital are located and the thyroid antibodies(X~22value=1.556,P =0.197).conclusion:1.The detection rate of thyroid antibody abnormalities among the staff of this hospital was 23.6%,and the overall detection rate of TPOAb was higher than that of TGAb;The abnormal thyroid function and antibody detection rate in female were significantly higher than that in male.The detection rate of thyroid antibody abnormalities was basically the same in the age groups of 20～30 years old,30～40 years old and 40～50 years old,and the age group of thyroid-related antibody abnormalities at50～60 years old was higher than the other age groups.2.Compared with the normal group,the thyroid antibody abnormal group had differences in gender,TSH,T3,FT4,FT3,RBC,Hb,TG,LDL. |
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