| Objective: The aim of the research is to analyze the relationship between TSH(Thyroid Stimulating Hormone),TPOAb(Thyroid Peroxidase antibody),Tg Ab(Thyroid globulin antibody)and micropapillary thyroid carcinoma(ptmc)in the blood of patients,and to further examine their clinical significance.To provide ideas for further research on the diagnosis of early thyroid cancer.Methods: Retrospectively,299 patients with thyroid ultrasound who attended the Department of Glandular and Vascular Surgery of the Affiliated Hospital of Yan’an University from October 2020 to October 2022 showed that the patients had TI-RADS 4a and 4b nodules with a diameter of less than 1 cm,and were divided into the micropapillary thyroid carcinoma group and the benign thyroid tumor group according to the postoperative pathology.For the micropapillary carcinoma group of thyroid gland,it was further divided into cervical lymph node metastasis group and non-lymph node metastasis group according to whether there was lymph node metastasis.Among them,there were154 patients with Papillary Thyroid Microcarcinoma,145 patients with benign thyroid nodules,299 patients with preoperative serum TSH,Tg AB,TPOAB concentration data were recorded,and 106 cases in the PTMC group had lymph node metastasis after radical thyroidectomy,and the data were statistically analyzed by SPSS-28.0 software.Relults:1.There was no significant difference between the sexes between the thyroid micropapillary carcinoma group and the benign thyroid tumor group(P > 0.05),and the age and BMI and TSH,Tg AB and TPOAB of the thyroid micropapillary carcinoma group were 47.85±10.22,24.49±3.80 kg/m~2,2.59(1.63,3.69),2.59(1.63,3.69),38.05(25.7,53.9)m IU/L,respectively.The corresponding values for benign thyroid tumors were 49.44±9.95,24.67±4.59 kg/m~2,1.62(0.98,2.23),16.7(12.3,22.7),31.3(21.75,40.25)m IU/L.There were significant differences in age and BMI(Body Mass Index)and TSH,Tg AB,TPOAB,thyroid micropapillary carcinoma group and benign thyroid tumor group(P < 0.05).2.Age,sex,and serum TPOAb were associated with cervical lymph node metastasis in the cervical lymph node negative group versus the cervical lymph node negative group,with statistically significant differences(P < 0.05).Regardless of BMI,there were no statistically significant differences in TSH or Tg Ab levels between the lymph node metastasis group and the lymph node negative group(P > 0.05).3.In the multivariate logistic regression analysis,it was found that TSH,BMI and age were all independent influencing factors for thyroid micropapillary carcinoma(P < 0.05).In addition,studies showed that TSH and BMI were positively correlated with thyroid micropapillary carcinoma(regression coefficients were 0.491,0.990,OR were 1.635,1.104,respectively).There was a negative association between age and thyroid micropapillary carcinoma(regression coefficient-0.037,OR 0.963)4.After plotting the ROC curves of TSH,Tg Ab,TPOAb level,BMI,age and micropapillary thyroid carcinoma,it was found that in the comparison of benign and malignant thyroid gland,the area under the curve corresponding to age and BMI and Tg Ab and TPOAb was less than 0.65.TSH corresponds to an area under the curve of 0.704,sensitivity of 0.545,specificity of 0.828,and a Jordon index of 0.373,corresponding to a TSH cut-off value of 2.465μU/m L.Conclusions:1.Age,BMI,TSH,Tg Ab and TPOAb were correlated with the occurrence of PTMC.Age,BMI and TSH were independent risk factors for PTMC.BMI and TSH were positively correlated,and age was negatively correlated.TSH can be used as an independent predictor of PTMC.When TSH > 2.465,the occurrence of PTMC should be alerted.2.Age,gender and TPOAb were correlated with cervical lymph node metastasis of PTMC,while TSH and Tg Ab were not correlated with cervical lymph node metastasis of PTMC. |
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