Study On The Correlation Between Low Density Lipoprotein Cholesterol And Diabetic Peripheral Neuropathy And The Therapeutic Effect Of Atorvastatin

ObjectiveThe study will compare lipid levels and other clinical markers among patients with diabetes to investigate the effect of LDL cholesterol levels on diabetic peripheral neuropathy and to observe the effect of atorvastatin on peripheral neuropathy in patients with diabetes.MethodPatients with type 2 diabetes who were treated in our hospital from June 2021 to June 2022 were selected as study objects according to inclusion and exclusion criteria.Through comprehensive evaluation of clinical manifestations,electromyography and other data of patients,they were divided into two groups: DPN group(diabetic peripheral neuropathy group),NDPN group(non-diabetic peripheral neuropathy group),50 patients in each group.General data,such as age,sex,weight,height,and blood pressure,were collected.Biochemical data,such as triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting blood glucose(FBG),and glycosylated hemoglobin(Hb Alc),were collected.In addition,the EMG data of patients who took atorvastatin for 3 months and 6 months were collected,a database was established to store the data,and SPSS26.0 software was used to statistically analyze the differences in various indicators between the two groups.Results1.There were no significant differences in age,sex,height,weight,BMI,SBP and DBP between the two groups(P>0.05).2.There were significant differences in TG,TC,HDL-C and LDL-C between DPN group and NDPN group(P<0.05).3.The MCV of common peroneal nerve was negatively correlated with TG(r=-0.425,P< 0.05);The SCV of superficial peroneal nerve was negatively correlated with TG(r=-0.291,P<0.05);Median nerve SCV was negatively correlated with TG(r=-0.472,P<0.05);Common peroneal nerve MCV was negatively correlated with TC(r=-0.561,P<0.05);The SCV of superficial peroneal nerve was negatively correlated with TC(r=-0.308,P< 0.05);Median nerve was negatively correlated with TC(r=-0.672,P<0.05);There was a negative correlation between MCV and LDL-C(r=-0.656,P< 0.05);The superficial peroneal nerve SCV was negatively correlated with LDL-C(r=-0.340,P<0.05);Median nerve SCV was negatively correlated with LDL-C(r=-0.802,p<0.05);There was a positive correlation between MCV and HDL-C(r=0.57,P<0.05);Superficial peroneal nerve SCV was positively correlated with HDL-C(r=0.311,P<0.05);Median nerve SCV was positively correlated with HDL-C(r=0.654,p< 0.05);4.Multiple linear stepwise regression analysis showed that the common peroneal nerve MCV was independently correlated with LDL-C and HDL-C(P< 0.05)and had no significant correlation with other factors.Superficial peroneal nerve SCV vs TG,TC,LDL-C,HDL-C had no significant correlation(P>0.05).Median nerve SCV was independently correlated with TG,LDL-C and HDL-C(P<0.05).,but had no significant correlation with other factors.5.The nerve conduction velocity of diabetic patients without and after 3 months of atorvastatin treatment was compared.The results showed that the common peroneal nerve MCV,superficial peroneal nerve SCV and median nerve SCV were significantly different between the two groups before and after treatment(P<0.05),and the nerve conduction velocity in each group after 3 months of medication was significantly higher than that before medication.Nerve conduction velocity was compared between patients who took atorvastatin for 3 months and those who took atorvastatin for 6 months.The results showed that the common peroneal nerve MCV,superficial peroneal nerve SCV and median nerve SCV were significantly different between the two groups before and after taking atorvastatin(P<0.05),and the nerve conduction velocity in each group after6 months of medication was significantly higher than that after 3 months of medication.Conclusions1.Serum levels of TG,TC and LDL-C in DPN group were higher than those in NDP group,and serum levels of HDL-C were lower than those in NDPN group,and the differences were significant(P<0.05).2.Correlation analysis showed that nerve conduction velocity was negatively correlated with TG,TC and LDL-C,and positively correlated with HDL-C.Combined with multiple linear regression analysis,HDL-C and LDL-C were independent predictors of abnormal nerve conduction velocity3.The nerve conduction velocity of the DPN group after taking atorvastatin for 3months was higher than that before taking atorvastatin,and the nerve conduction velocity of the DPN group after taking atorvastatin for 6 months was higher than that after taking atorvastatin for 3 months,suggesting that atorvastatin can improve peripheral nerve conduction velocity of DPN patients.