Study On Perioperative Health-related Quality Of Life And Its Risk Factors In Patients With Glioma

Objective To investigate the perioperative health-related quality of life and its influencing factors in patients with glioma.Methods Patients with glioma who visited our department for surgical treatment from May 2022 to April 2023 were selected using a convenience sampling method.and general demographic,clinical and surgery-related data were prospectively collected.The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ)C30 and BN20,and the Karnofsky Performance Scale(KPS)were used to measure the quality of life of the patients.KPS were assessed preoperatively and 7 days postoperatively,and the results of the scales were collected,compiled and analyzed.Results Eighty-eight of the 110 patients completed preoperative and 7-day postoperative quality of life measurements and were included in the final analysis.The study was divided into low and high level groups according to pathological findings,and the mean age of patients in both groups was:43.1±9.3 and 50.5±14.6,respectively,and the percentage of males was:54.8%and 57.9%,respectively.Patient’s overall health status,physical function.cognitive function,role function and social function decreased 7 days postoperatively compared to preoperatively.Fatigue.constipation,diarrhea,motor function,communication disorders,drowsiness symptoms and weakness of the legs symptoms were worse 7 days postoperatively than preoperatively.The tumor was located in the left cerebral hemisphere and social function worsened at 7 days postoperatively compared to preoperatively.The higher the KPS score the greater the change in diarrhea,motor function and limb weakness.Tumors located in the right cerebral hemisphere(β=25.8,P=0.001)significantly and positively predicted patient’s’ social functioning.Age>64 years(β=-19.7,p=0.027),high-grade glioma(β=-17.5,p=0.002),and KPS(β=-0.57,p=0.005)significantly and negatively predicted the degree of communication impairment in quality of life assessment.After 12 months of follow-up,the global health status gradually improved.Conclusions Health-related quality of life decreased 7 days after glioma surgery compared to preoperative in overall health status,somatic function,role function,cognitive function and social function dimensions;weakness,constipation,diarrhea,motor function,communication impairment,lethargy and limb weakness increased 7 days after surgery compared to preoperative.Surgery plays an important but traumatic role in the treatment of glioma,and the use of assessment tools to evaluate quality of life and to find influencing factors and intervene early can maximize the quality of life of postoperative patients and promote their recovery.