Development And Construction Of A Model For Early Screening Of Venous Thromboembolism Based On Human Infrared Thermodynamic Characteristics

Objective: To find an easy-to-use,economical,painless and safe test and diagnosis method as an auxiliary diagnosis and early screening tool for pulmonary vascular embolic diseases,and to standardize its screening scoring system,and then to combine it with the TCM physical typing by infrared thermography to facilitate the TCM dialectical intervention,so as to achieve the effect of prevention before illness and prevention after illness.Methods:1.By constructing an animal model of blood stasis evidence,the infrared thermo grams and color Doppler angiograms of the lower extremities of the animal model were captured at different time points,and then the animals were executed,the pulmonary vessels and lower extremity vessels were dissected to understand the site of obstruction and the size of the thrombus,and pathological sections were made,by comparing the characteristics of the infrared thermograms of the chest and both lower extremities.2.120 inpatients were randomly enrolled,perfected infrared thermography detection and TCM body type investigation,calculated the temperature difference d value of both lower extremities is to understand the distribution of temperature difference in different regions of lower extremities,and also classified them into d < 0.5℃,0.5 ≤ d < 1℃,and d > 1℃ according to the size of d value,and followed up their incidence of lower extremity deep vein thrombosis and pulmonary embolism within one year.Results: 1.The multisample U test suggested that,when comparing the v WF values between groups,the v WF values in the T3 group were higher than the other evidence types(p < 0.05),and the remaining differences between groups were not statistically significant;when comparing the FIB values between groups,T1 < T2(p < 0.05),T2 < T3(p < 0.05),and the differences between the T0 and T1 groups were not statistically significant;when comparing the AF-III values between groups,T1 < T2(p < 0.05),T2 < T3(p < 0.05),no statistically significant difference between T0 and T1 groups;comparison of D-Dimer values between groups,T1 < T2(p < 0.05),T2 < T3(p < 0.05);comparison of d values between groups,T1 < T2(p < 0.05),T1 < T3(p < 0.05),the remaining The differences between groups were not statistically significant.There was no statistically significant difference in the comparison of IL-1β,IL-6,SOD,and TNF-α between groups(p > 0.05);NO values between groups,T1 < T2(p <0.05),T1 < T3(p < 0.05),and no statistically significant difference between T0 and T1 groups,T2 and T3 groups.2.The Kruskal-Wallis H rank sum test suggested that the overall distribution of lower limb thrombus size was not the same in the four groups(P<0.05),that is,the overall distribution of lower limb deep vein thrombus size was different in the four groups;the overall distribution of pulmonary artery thrombus size was not the same in the four groups(P<0.05);the distribution of bilateral limb The distribution of temperature difference between the four groups of rabbits was different(P<0.05),that is,there were differences in the distribution of bilateral limb temperature in the four groups,and the difference in temperature between the bilateral limbs was greater in the T3 group.3.In the clinical study,the incidence of lower extremity deep vein thrombosis in group C was statistically significant(p < 0.05)compared with group A and group B.The difference between group A and group B was not statistically significant;the difference in the incidence of pulmonary embolism in each group was statistically significant(p < 0.05),and the difference between the two groups: group C → group B → group A decreased in order;the chi-square test suggested that the difference between D-Dimer and WELL scores in groups A and B was not statistically significant(both p > 0.05);the difference between D-Dimer and WELL scores in group C was higher than in groups A and B,and the difference between the two groups was not statistically significant(p > 0.05).The difference in D-Dimer and WELL scores between groups A and B was not statistically significant(both p>0.05);the difference in D-Dimer and WELL scores between group C and group A and group B was higher,and the difference between the two groups was not statistically significant(p>0.05).4.There was a statistically significant difference in the incidence of lower limb deep vein thrombosis in each group in the clinical study(P < 0.05),and the two comparisons: qi-depression and blood stasis → yang-deficiency and blood stasis→ qi-depression and blood deficiency in that order.There was also a statistically significant difference in the incidence of pulmonary embolism in each evidence type(P < 0.05),and the two comparisons: Qi-depression and blood stasis → Yang-deficiency and blood stasis → Qi-depression and blood deficiency in that order.Conclusions: 1.PTE has rapid onset and development,and 90% of the thrombi causing pulmonary vascular embolism originate from DVT;therefore,active and effective prevention can significantly reduce the formation of deep vein thrombosis and decrease the incidence of PTE.2.The incidence of deep vein thrombosis is high when the limb temperature difference d value is >1℃,and it is consistent with simplified Wells score and D-dimer.Infrared thermography can be used as an adjunctive diagnostic tool for pulmonary embolism and lower limb deep vein thrombosis.3.Infrared thermography can indirectly respond to the site of obstruction in vasoembolic disease,and infrared thermography can be used as a novel detection and screening tool for DVT in lower extremity deep vein thrombosis,which is important for early diagnosis of VTE.4.The incidence of lower limb deep vein thrombosis and pulmonary embolism was significantly higher in people with qi-depression and blood stasis and yang-deficiency and blood stasis than in people with other body types.