| Objective:Around 340 million people worldwide suffer from depression/anxiety.Depression/anxiety is a common mental disorder with high disability rate.About 68.91%of neurology inpatients had depression/anxiety,Anxiety disorders often go hand in hand with depression.Depression/anxiety disorders are highly prevalent and harmful,causing great harm to sufferers and even their families.The current clinical evaluation of depression/anxiety is mainly based on the scale score.However,the disadvantage of the scale is that it is easy to be affected by subjects’ subjective will,honesty and stigma,and requires the cooperation of subjects’ cognition and listening,and the testers need to go through professional training.Therefore,there is currently a lack of objective clinical methods to assist the identification of depression/anxiety states.Studies have suggested that anomaly in the raphe nucleus echogenicity detected by transcranial ultrasound are associated with depression associated with certain neurological diseases,Including Parkinson’s disease,epilepsy,migraine,stroke,Huntington’s disease,idiopathic REM sleep behavior disorder.However,studies on the correlation of BR echogenicity anomaly with depression/anxiety in general neurology inpatients are lacking.In addition,the relevant factors causing the anomaly of BR echogenicity are still unclear.The purpose of this study was to examine the correlation between depression/anxiety and altered BR echogenicity in neurology inpatients.To explore whether the BR echogenicity can be applied to this population and help to evaluate anxiety/depression;In addition,the related factors of BR echogenicity anomaly were further analyzed from clinical data to explore the potential mechanism.Methods: 1.Patients admitted to the Department of Neurology of our hospital from May 2019 to January 2023 were collected under the condition that the patients signed informed consent.Improve HAMD and HAMA assessment and TCS examination.General clinical data were collected,including gender,age,education level,smoking history,drinking history,history of hypertension,diabetes,coronary heart disease and stroke,as well as blood test results and other relevant indicators.2.Grouping was performed according to HAMD and HAMA scales to analyze the correlation between BR echogenicity anomaly and hospitalization with depression/anxiety in neurology department.3The factors influencing BR echogenicity results were analyzed from clinical data and blood tests.Results:A total of 412 patients admitted to the Department of Neurology were enrolled in this study,including 215 males and 197 females.According to the types of diseases,264 cases of cerebrovascular disease,65 cases of peripheral vertigo,32 cases of neurodegenerative diseases,23 cases of peripheral neuropathy,18 cases of headache,and 10 other cases.Among them,ischemic cerebrovascular disease accounted for 64.1%. Firstly,the dichotomy method was used to verify the correlation between depression/anxiety status and BR echogenicity in neurology inpatients.The results showed that the number of abnormal BR echogenicity in the depression/anxiety group was significantly higher than that in the normal BR echogenicity group,but no statistical difference was found(P=0.078 in the depression group and P=0.546 in the anxiety group).To further explore the correlation between depression/anxiety status and BR echogenicity in neurology inpatients,Adjust the groups according to the scale scoring criteria.The first step is still a dichotomy,divided into no or mild depression group,moderate or above depression group,Between the two groups,the results showed that gender,drinking history,smoking history,BR echogenicity and anxiety/depression were statistically significant(P < 0.05).There were no significant differences in age,education level,previous stroke history,hypertension history,diabetes history and coronary heart disease history among groups(P > 0.05).Step 2: According to the scale scoring standard and BR echo grading of transcranial ultrasound imaging,There was a statistically significant difference in anxiety degree between the 5 groups and the echo results of BR(statistical value = 34.034,P=0.000).There was a significant difference in depression degree between the four groups and the results of raphe nucleus echo(statistical value = 23.316,P=0.001).The correlation analysis of the degree of anxiety/depression and the anomaly of BR echogenicity in the inpatients of neurology department showed that the difference of the degree of anxiety(r=0.198,P=0.000),the degree of depression(r=0.203,P=0.000)and BR echogenicity was statistically significant and positively correlated.In the analysis of factors related to BR echogenicity anomaly,the BR echogenicity anomaly of non-neurodegenerative patients hospitalized in the Department of Neurology showed a statistical difference in smoking history(statistical value = 4.865,P=0.027).The results showed that BR echogenicity were more likely to be abnormal in non-neurodegenerative patients admitted to the Department of neurology without a history of smoking.There were no significant differences in gender,age,education level,drinking history,past history and blood test results in the remaining groups(P >0.05).Age was grouped into different stages,and the correlation between BR echogenicity and age was deeply analyzed.The results showed that there was no statistical difference between BR echogenicity anomaly and age in inpatients of neurology department.Conclusion:1.Female were more likely than male to report depression/anxiety among neurology inpatients.2.Neurology inpatients with no history of smoking or alcohol use were more likely to have depression/anxiety.3.The degree of depression/anxiety in neurology inpatients was clearly correlated with the degree of BR echogenicity abnormality.TCS may be considered as a simple test to assist in screening for a certain degree of depression/anxiety in neurology inpatients.4.Patients admitted to the Department of Neurology without neurodegenerative diseases were more likely to have abnormal BR echogenicity without a history of smoking.5.There was no statistical difference between BR echogenicity anomaly and age in neurology patients. |
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