| Cinnamomum is the dried bark of cinnamon(Cinnamomum cassia Presl),a plant of the Lauraceae genus in the Lauraceae family,also known as Yugui,Mugui,Jungui.It was recorded in the Sheng Nong’s herbal classic that cinnamomum tasted spicy,curing hundreds of diseases,nourish Jingshen,healthy for joint,tonifying middle-Qi,and was listed as the superior traditional Chinese Medicine.Having the effect of warming the Qi and Xue,toning and helping the Yang,invigorating Huo and returning Yuan,dissipating cold and relieving pain,warming and opening up the meridians.Used for asynodia and uterine cold,cold and pain in waist or knee,kidney deficiency with asthma,circumgyration,cold and pain in abdomen or heart,cold causes vomiting and diarrhea,cold hernia and abdominal pain,dysmenorrhea and amenorrhea.Cinnamomum has become one of the most widely used medicines in Traditional Chinese prescriptions due to its long medication history and definitive efficacy.Through a lot of scientific researches,it is found that cinnamaldehyde,flavonoids,polyphenols,lignans,terpenes,polysaccharides and other chemical components are contained in cinnamomum.Base on the significant clinical application effect of cinnamomum,the following jobs had done on this study:1.A specific review of the traditional applications,isolated sesquiterpenoids and diterpenoids and their biological activities of Lauraeace plants was provided.A specific review of the prescriptions,chemical compounds and pharmacological effects of C.cassia was provided.2.18 compounds were obtained from cinnamomum n-butanol extraction which were systematically separated by thin-layer chromatography,silica gel column chromatography and gel column chromatography.The chemical structures of isolated compounds were determined by spectroscopic methods such as UV,IR,HR-ESI-MS and NMR,these compounds were identified as cinncassiol H(1)、anhydrocinnzeylanine(2)、(7S,8R)-guaiacylglycerol-β-coniferyl aldehyde ether(3)、(7R,8R)-guaiacylglycerol-β-coniferyl aldehyde ether(4)、cinnacassin L(5)、(2R,3R)-3-hydroxy-5,7-dimethoxy-4’,5’-methylenedioxy flavan(6)、clovandiol(7)、(1R,3S,6S,7R,10S)-7-isopropyl4,10-dimethylbicyclo[4.4.0]dec-4-en-3,10-diol(8)、cassiferaldehyde(9)、syringaldehyde(10)、(-)-cinnamic acid(11)、coumarin(12)、(1R,2R)-1-phenylpropane-1,2,3-triol(13)、α-D-glucopyranose(14)、β-D-glucopyranose(15)、β-D-furanofructose(16)、β-D-fructopyranose(17)、α-D-furanofructose(18),and 1 is a new compound.3.Zebrafish model of copper sulfate immersion induced inflammation,inflammation model induced by injection of LPS into yolk sac and model of transecting zebrafish tail were used to performed the anti-inflammatory activity of 1、5、7 and 8.The experimental results showed that 5 had a certain anti-inflammatory activity in zebrafish copper sulfate immersion inflammation model at the concentration of 20-40 μM;1、7 and 8 had anti-inflammatory activity at 25-100 μM in three inflammation models.4.Filter-paper-disk methol was used to perform antimicrobial activities screening of escherichia coli,canidia albicans,porphyromonas gingivalis,helicobocton pyloni and solobacterium moorei by the total ethanol extraction(RGA),petroleum ether extraction(RGP),ethyl acetate extraction(RGE),n-butanol extraction(RGB)and water extraction of cinnamomum(RGH).The experimental results showed that RGA at 100 mg/mL,RGP at 50-100 mg/mL,RGE at 50-100 mg/mL and RGB at 50-100 mg/mL showed antibacterial activity against canidia albicans.RGP at 75-100 mg/mL showed antibacterial activity against escherichia coli.RGA,RGP,RGE and RGB showed antibacterial activity against porphyromonas gingivalis and helicobocton pyloni at 50-100 mg/mL.RGH showed no antibacterial activity against any of the above strains at the tested concentrations and none of the extractions showed antibacterial activity against solobacterium moorei at tested concentrations. |
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