A Meta-analysis Of The Association Between Brain-derived Neurotrophic Factor And Type 2 Diabetes Mellitus And Its Complications

Objective: This study aims to comprehensively evaluate the correlation between brain-derived neurotrophic factor(BDNF)and type 2 diabebetes mellitus(T2DM)and its complications through Meta-analysis method,and further Explore the influence of different factors on this association.Methods: By searching Chinese and English databases,with a search period from the establishment of the literature database to August31,2022,we collected all published case-control studies,cohort studies,and cross-sectional studies investigating the association between BDNF and diabetes.The literature was independently screened and data extracted by different evaluators in strict accordance with predetermined inclusion and exclusion criteria.The quality of the included studies was rigorously evaluated,and meta-analysis was performed using Review Manager 5.4software.Results: A total of 26 studies were included in this analysis,comprising 1738 controls,2024 patients with type 2 diabetes mellitus(T2DM),431 patients with diabetic peripheral neuropathy(DPN),and 379 patients with diabetic retinopathy(DR),including 144 patients with non-proliferative diabetic retinopathy(NPDR)and 142 patients with proliferative diabetic retinopathy(PDR).The results showed that compared with the control group,the blood BDNF level was significantly decreased in the T2DM group [WMD=-1.08,95%CI(-1.24,-0.92),P<0.00001].The blood BDNF level in the T2DM group wassignificantly higher than that in the DPN group [ WMD= 0.57,95 %C I(0.24,0.89),P=0.00006].The blood BDNF level in the T2DM group was higher than that in the DR group,but the difference was not statistically significant [WMD=0.90,95%CI(-0.12,1.91),P=0.08].No statistically significant difference was observed in the serum BDNF levels between the groups with NPDR group and PDR group [WMD=-0.20,95%CI(-0.95,0.56),P=0.61].To validate the results,meta-analyses were further performed between the control and DPN groups and between the control and NPDR groups,and no significant differences were found between these groups [WMD=-1.92,95%CI(-4.41,0.57),P=0.13 and WMD=-0.23,95%CI(-0.79,0.34),P=0.43,respectively].Conclusion: Blood BDNF may be associated with the occurrence of type 2 diabetes mellitus and diabetic peripheral neuropathy.