Effect Of Early Chewing Gum On Gastrointestinal Motility And Related Gastrointestinal Hormone Levels In Small Bowel Capsule Endoscopy

Objective To study the value of early chewing gum on gastrointestinal transit time of small bowel capsule endoscopy、small-bowel lesion detection rate、whole small-bowel detected completion rate and its influence on the regulation of related gastrointestinal hormone levels,and to explore its clinical effect and its correlation with gastrointestinal hormone changes.Methods The patients who underwent small bowel capsule endoscopy were divided into early gum chewing group(gum group)and routine nursing group(control group)according to the random digital dialing method.The endoscopy capsule transit time in stomach and small intestine,1-hour pyloric transmit rate,2-hour pyloric transmit rate,small-bowel lesion detection rate,whole small-bowel detected completion rate,Gastroscopy intervention rate,and the regulation of gastrointestinal hormone levels were compared.Results A total of 80 patients were enrolled in this study and divided into gum group and control group,with 40 patients in each group.First,there was no significant difference in baseline characteristics between the two groups(p>0.05).Secondly,the study found that compared with the control group,the gastric transit time of small bowel capsule endoscopy in the chewing gum group was significantly reduced[(36.13±23.14)min vs.(55.40±37.90)min,P=0.008],however,the 1-hour pyloric transit rate and the completion rate of total intestinal examination were significantly increased(90.0%vs.60.0%,P=0.002;100%vs.85.0%,P=0.034),and there was statistical significance;Third,compared with the control group,the detection rate of small intestinal lesions,the two-hour pyloric passage rate in the chewing gum group increased(60.0%vs.62.5%,P=0.818;100%vs.92.5%,P=0.239)and the intestinal passage time between the two groups[(354.85±174.82)min vs.(358.68±188.54)min,P=0.925]was no significant difference;fourth,the acetylcholine(ACh)The content of VIP(Vasoactive endogenous peptide)had no significant change(P>0.05);Finally,we found that compared with the control group,the serum Motilin(MTL)of patients in the chewing gum group was significantly higher at 1 hour after examination[(7.67±2.31)ng/ml vs.(6.08±2.45)ng/ml,P=0.0043],while the concentration of Cholecystokinin(CCK)was significantly lower[(3.39±0.84)ng/ml vs.(3.89±0.64)ng/ml,P=0.0040],both of which had statistical significance(P<0.05).Conclusion Short time gum chewing enhances gastric transit time and the small bowel detected completion rate,but doesn’t affect the transmit time of small bowel capsule.This may be related to the simultaneous regulation of motilin and cholecystokinin by chewing gum,and this method is simple,safe,effective and suitable for clinical promotion.