| Objective:To investigate the clinical characteristics of patients with severe ventricular arrhythmias complicated with coronary lesions undergoing radiofrequency ablation,and analysis the correlation between severe VAs and coronary lesions.Methods:A total of 76 patients with severe VAs undergoing RFA in the Department of Cardiac Medicine of the Affiliated Hospital of Guizhou Medical University from January 2014 to December 2021 were analyzed retrospectively.The general data,initial laboratory results at admission,echocardiographic data,coronary angiographic data,electrophysiological data and RA data of the included patients were collected.According to Gensini score,the patients were divided into non-coronary lesion group(Gensini score = 0,n = 37)and coronary lesion group(Gensini score > 0,n = 39).Further,the patients with Gensini score > 0 were subdivided into group A(n = 15,0 <Gensini score ≤ 4),group B(n = 13,4 < Gensini score ≤ 10)and group C(n = 11,Gensini score > 10)using tertiles.Additionally,the patients were divided into ventricular premature beat group and ventricular tachycardia group based on the type of VAs,and left ventricle group and right ventricle group based on the origin.The statistical significance of different indexes between each group was analyzed,and the data correlation was analyzed by the Spearman’s rank correlation test.Results:Gender,chest tightness,smoking history,drinking history and history of dyslipidemia showed statistically significant differences between the non-coronary lesion group and the group A,B and C(P < 0.05),but no statistically significant differences were found between the ventricular premature beat group and the ventricular tachycardia group,and the left ventricle group and the right ventricle group(P > 0.05).The group A,B and C were further compared with the non-coronary lesion group one by one.The group A showed no significant differences with the non-coronary lesion group(P > 0.05).In the group B,the proportions of males,chest tightness and drinking history were higher than those in the non-coronary lesion group(P < 0.05).In the group C,the proportions of chest tightness,smoking history,drinking history and history of dyslipidemia were higher compared with the non-coronary lesion group(P < 0.05).Echocardiographic indexes presented no statistically significant differences between each group(P > 0.05).Statistically significant differences were observed in laboratory indexes such as TG and TG/HDL between each group(P < 0.05).According to comparison between the group A,B and C and the non-coronary lesion group,no statistically significant differences were detected between the group A and B and the non-coronary lesion group(P > 0.05),and TG and TG/HDL-C levels in the group C were higher than those in the non-coronary lesion group(P < 0.05).According to Gensini score,the indexes were assigned as 0,1,2 and 3,and subjected to Spearman’s rank correlation analysis,revealing that male(r = 0.315,P = 0.006),chest tightness(r = 0.297,P = 0.009),smoking history(r = 0.273,P = 0.018),drinking history(r = 0.249,P = 0.030),history of dyslipidemia(r = 0.239,P = 0.038),TG at admission(r = 0.291,P =0.011),TG/HDL(r = 0.305,P = 0.007)had significantly positive correlations with the degree of coronary lesions.However,the origin and type of VAs were not significantly correlated with the degree of coronary lesions(P > 0.05).VAs of different types showed no statistically significant differences in culprit vessels or Gensini score(P > 0.05).Spearman’s rank correlation analysis demonstrated no correlations of different types and origins of VAs with the site of each coronary lesion(P > 0.05).Conclusions:1.Gender,smoking history,drinking history,high TG,high TG/HDL-C ratio and chest tightness may be correlated with coronary lesions in patients with severe VAs.2.It is difficult to evaluate the presence of coronary lesions and their site and degree only based on the type and origin of severe VAs. |
PDF Full Text Request