External Application Of Xiaoyan No.1 Prescription Combined With Qingjiang Decoction For Oral Administration Observation And Research On Clinical Efficacy In The Treatment Of Plasma Cell Mastitis

Objective:To compare and observe the different therapeutic effects on plasma cell mastitis of 3kinds of treatment schemes of Ruyi Jinhuang Powder and Rupishu Capsules,Xiaoyan No.1 Formula and Rupishu Capsules,and Xiaoyan No.Provide more choices of traditional Chinese medicine for the treatment of plasma cell mastitis,and enhance the confidence of female patients with this disease in the region to protect breast.Methods:A total of 83 patients who were diagnosed with plasma cell mastitis in the TCM Breast Clinic of the First Hospital of Shanxi Medical University from October 2020 to December 2021 were collected and randomized,double-blind,and positive drug parallel.Clinical observation in the control trial,A(positive control group)was treated with Ruyi Jinhuang Powder for external application and Rupishu Capsule for oral administration;B(control group)with Xiaoyan No.1 Formula for external application and Rupishu Capsule for oral administration;C(experimental group)with anti-inflammatory No.1formula is externally applied and Qingjiang Decoction granules are taken orally.One month is a course of treatment.Syndrome score,effective index(n)and short form of health survey(SF-36)score were observed outcome indicators,which were evaluated once before treatment,1 month after treatment,2 months after treatment,and 3 months after treatment.SPSS 22.0 statistical software was used to process data.When measurement data obeyed normal distribution,it was expressed as mean±standard deviation(?x±s),and the comparison between groups was analyzed by variance analysis;the count material will be expressed as cases(%),and the comparison between groups was expressed byχ~2test.and Fisher’s exact probability method;repeated measures data were analyzed by variance analysis of repeated measures data,and p<0.05 indicated that the difference was statistically significant.Results:1.Before treatment,a significant difference in the symptoms could not be noted of the three groups A,B,and C,P>0.05;after 1 month of treatment,the symptom scores of the Group C when accounted for were significantly lower when they were compared to those of the A and B groups,and a statistically significant difference was apparent(P<0.05);after 2 months of treatment,the symptom score of group B was significantly lower than that of group A(P=0.023);after 3 months of treatment,the symptom score of group C was significantly lower than that of groups A and B,and there was no symptom score between A and B significant differences.2.The curative effect index of the three groups A,B and C after treatment for 1month,2 months and 3 months after treatment all increased significantly.After a month of treatment had passed the curative effect index between A-C(P<0.001)and B-C(P<0.001)was significantly different,and the curative effect index of group C was significantly higher than that of groups A and B;there were significant differences in the efficacy indexes among the three groups.The efficacy index of group C was significantly higher than that of group A(P<0.001)and group B(P<0.001),and the efficacy index of group B was significantly higher than that of group A(P=0.021);after 3 months of treatment,there was a significant difference in the efficacy index between A-C(P=0.002)and B-C(P=0.002),and there was no significant difference in the efficacy index between A and B.3.Compared with before treatment,the scores of SF-36 scale in the three groups A,B and C were significantly increased in 1 month,2 months and 3 months after treatment.After 2 months of treatment,there were significant differences in the SF-36 scale scores between A-C(P<0.001)and B-C(P=0.001),and the SF-36 scale scores in group C were significantly lower than those in groups A and B.There were no significant differences in the SF-36 scale scores between the two groups.Conclusion:1.When Rupishu Capsule was chosen as the oral treatment drug,the medium-term curative effect of Xiaoyan No.1 formula group was better than that of Ruyi Jinhuang ointment group.2.When Xiaoyan No.1 is selected for external application,Qingjiang Decoction has a faster effect than Rupishu Capsule,and the observed long-term effect is more durable.3.The external application of Xiaoyan No.1 prescription combined with the addition and subtraction of Qingjiang Decoction has a certain curative effect,which can quickly relieve symptoms,prevent disease progression,and ideally preserve breast.