Correlation Analysis Between Lung Cancer And Red Blood Cell Distribution Width And D-dimer

Aims:To explore the relationship between the distribution width of peripheral blood red blood cells and D-dimer and lung cancer.Methods:A retrospective selection of 262 patients with primary lung cancer who were diagnosed by pathological diagnosis and untreated from June 2019 to February 2022 in the Second Affiliated Hospital of Nanchang University,Nanchang City,Jiangxi Province,and a healthy control group were selected.100 cases were screened by the Big Data Physical Examination Center.Primary lung cancer can be roughly divided into the following types according to histopathological types: squamous cell carcinoma,small cell carcinoma,adenocarcinoma,large cell carcinoma,adenos-quamous carcinoma,sarcomatoid carcinoma,carcinoid,salivary gland carcinoma,no Classification of cancer,etc.There were a total of 262 valid cases in lung cancer staging.A total of 133 lung cancer patients were classified as stage Ⅰ and Ⅱ by clinical staging results,and divided into one group,and the clinical results were assessed as stage Ⅲ and Ⅳ.For patients,when staging is in dispute,a third-party re-staging is performed.In the classification of lung cancer,the case group was roughly divided into two groups,with multiple common adenocarcinomas as one group,with a total of 190 cases,and other types of lung cancer such as squamous cell carcinoma,carcinoid,and sarcomatoid carcinoma were classified into the second group,a total of 72 cases.Clinical data such as age,gender,smoking history,infection history and pleural effusion history of lung cancer patients,as well as laboratory test results such as red blood cells,hemoglobin,white blood cells,red blood cell distribution width,fibrinogen,platelets,D-dimer and INR were collected.Results:Statistical analysis showed that the TT,Hb,MCHC,MCH,RBC and LY% of the lung cancer patient group were significantly lower than those of the healthy control group(P<0.05),with statistical significance.The D-2-mer,WBC,PTsec,Fib,RDW-CV and NEUT% were all higher than those in the healthy control group(P<0.05),with statistical significance.In the staging of lung cancer patients,D-2mer,INR,PT,Fib,WBC,Plt and NEUT% in stage III and IV lung cancer patients were higher than those in stage I and II lung cancer patients(P<0.05).The Hb,RBC and LY% of patients with stage III and IV lung cancer were lower than those of patients with stage I and II lung cancer(P<0.05).In the classification of lung cancer patients,INR,PT,PT%,Fib,and LY% were tested by Mannwhitney-U(P<0.05),and the difference between groups was statistically significant.Multivariate Logistic binary regression analysis was used to study the influence of D-2-mer,Fib,TT,PT,WBC,Hb,RBC,HCT,MCH,MCHC,RDW-CV and NEUT% on lung cancer patients.(P<0.05)as the standard,with statistical significance.Using Jizhiyun analysis software to perform binary regression analysis on the above indicators,and using forward and wald to screen the indicators,it was found that D-dimer and RDW-CV were independent influencing factors of lung cancer,with statistical significance(P<0.05).The area of the curve(AUC)of D-2-mer was 0.946.When the cut-off value was 0.330,the sensitivity was 86.6%,the specificity was 92.5%,and the Youden index was 0.791;the red blood cell distribution width(RDW-CV)was The area of the curve(AUC)was 0.732,and when the cut-off value was 12.7,the sensitivity was71.2%,the specificity was 66.3%,and the Youden index was 0.374.Conclusion:(1)Serum red blood cell count and hemoglobin in lung cancer patients decreased with the increase of clinical stage,while D-dimer,leukocyte,platelet,fibrinogen,and red blood cell distribution width increased with the increase of clinical stage.(2)Both red blood cell distribution width and D-dimer are independent risk factors for lung cancer patients.The AUC value of the combination of red blood cell distribution width and D-dimer in the diagnosis of lung cancer is the highest,which can be used as a good indicator to assist in the diagnosis of lung cancer.