Clinical Observation Of Modified Wuling Powder Combined With Febuxostat In The Treatment Of Gouty Arthritis Due To Spleen Deficiency And Dampness

Objective: To observe the clinical efficacy and safety of self-made modified Wuling powder combined with febuxostat in the treatment of gouty arthritis due to spleen deficiency and dampness in the non-acute stage.Methods: According to the research standard of case design,66 patients with gouty arthritis(cold dampness)who met the standard were randomly divided into the experimental group and the control group,with 33 cases in each group.Control group: oral administration of febuxostat tablets,40 mg once a day and general basic treatment;experimental group: combined with self-made modified Wuling powder on the basis of control group,twice a day,1 bag in the morning and evening,after meals Warm clothes for 0.5 hours;both groups were treated for 2 consecutive courses of treatment,and a course of treatment lasted 7 days.If during the treatment,the subject has an acute attack of GA,colchicine tablets or non-steroidal anti-inflammatory drugs can be given temporarily,and the original treatment plan can be continued after the pain is relieved.,SUA value,VAS score,GA TCM syndrome total score,number of recurrences,efficacy evaluation criteria and occurrence of adverse reactions 2 weeks after the end of treatment,and statistical software spss26.0was used for data that met and completed this study.To discuss and evaluate the differences in the clinical comprehensive efficacy of the two groups in the treatment of gouty arthritis due to spleen deficiency and dampness.Results: 1.Among the 66 patients,6 patients were dropped out due to factors such as loss to follow-up during the treatment process.Finally,a total of 60 patients completed the control experiment,30 patients in each group.The gender,age,course of disease,family history of gout,and comorbidities of the two groups of subjects History and pre-test SUA value,TCM syndrome score,VAS score,etc.were not statistically significant(p>0.05),suggesting that there was no significant difference between the two groups,and they were comparable.2.After 2 weeks of treatment: the SUA value in the two groups,the curative effect of control SUA,the total score of TCM syndromes,and the VAS score were all decreased and improved compared with those before treatment,and the difference was statistically significant(p<0.05),which was better than that after treatment.There were statistically significant differences in SUA value,TCM syndrome total score,and VAS score between the two groups(p<0.05),and the experimental group was significantly better than the control group.3.2 weeks after treatment: the SUA value in the two groups,the curative effect of control SUA,the total score of TCM syndromes,and the VAS score were significantly different from those before treatment(p<0.05).significantly better than before treatment.There were statistically significant differences in SUA value,total score of TCM syndromes,and VAS score between the two groups(p<0.05),and the experimental group was better than the control group.4.Gout recurrence rate: During the test period,the number of acute recurrences of gouty arthritis in the two groups,the control group had 2 cases,the total attack rate was 6.7%,and the experimental group had 1 case,the total attack rate was 3.3%.Statistical difference(p>0.05).5.Comparison of clinical efficacy: After 2 weeks of treatment,according to the efficacy of the TCM syndrome score table,the control group was clinically cured in 1 case,markedly effective in 3 cases,improved in 22 cases,and ineffective in 4 cases,with a total effective rate of 83.33%,and the experimental group was clinically cured.2 cases,markedly effective in 27 cases,improved in 0 cases,and ineffective in 1 case,with a total effective rate of 96.66%.According to the evaluation of the efficacy of lowering blood uric acid,in the control group,6 cases were clinically markedly effective,16 cases were effective,and 8 cases were ineffective,with a total effective rate of 80%.In the experimental group,13 cases were markedly effective,15 cases were effective,and 2 cases were ineffective,with a total effective rate of 93.3%.The differences between the two groups were statistically significant(p <0.05),and the experimental group was better than the control group.6.Comparison of safety indicators: During the treatment process,2 cases in the control group had gastrointestinal discomfort after treatment,and they could return to normal without treatment.There were 28 cases in grade 1 and2 cases in grade 2,and adverse reactions occurred.The rate was 6.67%.There were 4 cases in the experimental group who had gastrointestinal discomfort such as abdominal distension and nausea after treatment,which could be relieved without treatment.There were 26 cases in grade 1 and 4 cases in grade 2.The incidence of adverse reactions was 13.33%.The incidence of adverse reactions was not statistically significant(p>0.05).There was no significant difference in blood routine,liver and kidney function between the two groups before and after treatment,and no other adverse reactions such as dizziness,chest tightness,and drug allergic reactions occurred.Conclusion: Self-made modified Wuling powder combined with febuxostat can effectively treat gouty arthritis due to spleen deficiency and dampness sleepiness,and the effect is better than that of febuxostat alone.Scores and VAS pain scores,the incidence of adverse reactions was not significantly different from that of febuxostat alone,and the safety was good.It shows that the self-made modified Wuling powder combined with febuxostat is safe and effective,and it is worthy of further expansion of clinical research and promotion.