| Objective: The present study aimed to evaluate the effect of albumin to γ-glutamyltransferase ratio(AGR)on prognosis of primary liver cancer after radiofrequency ablation.Methods: A retrospective study was carried out on 112 liver cancer patients who were treated with radiofrequency ablation in the Affiliated Tumor Hospital of Guangxi Medical University from June 2009 to September 2018,and collected their clinical data.The receiv er operating characteristic curve(ROC curve)of AGR ratio for prognosis of liver cancer after radiofrequency ablation was drawn based on the 5-year survival rate of patients,which determined the optimal cut-off point of AGR ratio.Then,according to the cut-off point,all patients were divided into two groups: high AGR group and low AGR group.Collecting relevant information,including age,sex,Barcelona stage,The start time of radio frequency,tumor site,tumor number,ascites,hepatitis b surface antigen,gamma glutamine transferase,hepatitis c antibody,hepatitis b virus DNA,hemoglobin,total bilirubin,alanine aminotransferase,aspertate aminotransferase,white blood cell count,AFP,prothrombin time,international standardization ratio(INR),seru m prealbumin,albumin.Analyzed the relationship between these factors and the high and low AGR groups,We considered that the difference was statistically significant when P<0.05.Kaplan-Meier method was used to evaluate the OS and DFS of patients in the two groups,Draw the K-M curve,performed COX single factor regression analysis,and factors with P<0.05 in univariate analysis were included in multivariate analysis.Finally,the independent risk factors that affect the prognosis of patients with liver cancer after radiofrequency ablation are obtained.Results: This study included 112 patients with HCC,71 in the high AGR group and 41 in the low AGR group.The optimal cut-off point value of AGR was 0.45.AGR was closely related to the increase of alanine aminotransferase and aspartate aminotransferase,and there was no significant difference in the variables of the other two groups of data.Univariate analysis showed that cirrhosis,splenomegaly,positive ascites,positive pleural effusion,Child-Pugh scores,tumor number,albumin level and AGR were risk factors for OS in patients with liver cancer after radiofrequency ablation.Multivariate analysis showed that the ascites was positive[HR: 3.248,95%CI:(1.276,8.268),P: 0.013],The number of tumors were more than 2[HR: 3.343,95%CI:(1.473,7.584),P: 0.004],and the albumin level was lower than 35g/L,AGR<0.45[HR : 2.208,95%CI:(1.101,4.430),P : 0.026].However,Univariate analysis showed that the risk factors for DFS after radiofrequency ablation in HCC patients were cirrhosis,HBV DNA expression,and AGR,in multivariate analysis,P values were all higher than 0.05.AGR was not an independent risk factor for predicting recurrence after radiofrequency ablation in HCC patients.Conclusion: The albumin to γ-glutamyltransferase ratio(AGR)is an independent risk factor for overall survival of patients with primary liver cancer after radiofrequency ablation,which has certain clinical value.Patients with an AGR<0.45 before radiofrequency ablation had worse overall survival than those after treatment. |
