| This study aimed to investigate the effects of maternal lipopolysaccharide(LPS)challenge and dietary fat sources on colostrum quality and inflammatory response in sows.This experiment was conducted to using 60 Landrace × Yorkshire sows at parity(3-5)were randomly assigned to 3 dietary treatments,with 20 replicates per treatment and 1 sow per replicate,supplemented with 3% soybean oil(SO),3% coconut oil(CO)or 3% fish oil(FO),respectively,and consistent levels of other nutrients,which was applied to sows from Day 90 of gestation until parturition.On Day 112 of gestation,the sows from each dietary treatment were randomly assigned to 2 treatments and injected intramuscularly with LPS(10 μg/kg body weight)or saline.The results showed that LPS challenge and dietary oil type had no significant effects on reproductive performance of sows(P > 0.05).But the average weight gain of piglets from LPS-challenged sows was decreased compared to the saline-treated group(P < 0.01).Maternal LPS challenge decreased colostrum yield(P < 0.05),dry matter content(P < 0.01)and colostrum intake in piglets(P < 0.01).The concentrations of pro-inflammatory cytokines interleukin-6(IL-6)、interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in colostrum were affected by the interactive effect of oil type and LPS(P < 0.01).The LPS challenge increased the contents of IL-6、IL-1β and TNF-α in colostrum compared to the saline-treated group(P < 0.01),which the group fed the CO diet was most affected,and the group fed the FO diet had a lower response.Maternal LPS challenge increased the mRNA abundance of IL-6、IL-1β and TNF-α and the phosphorylation level of p65 in mammary glands(P < 0.01).However,the responses of these variables to LPS treatment were lower in sows fed a FO diet.Overall conclusions: The inclusion of FO in sow gestation diets exerted anti-inflammatory effects in the mammary glands of sows and counteracted the LPS-induced pro-inflammatory response when compared to CO. |
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