Linear Tribo-piezoelectric Nanogenerator Based On Au-PDMS/PVDF For Micropressure Sensing And Energy Conversion In Vivo

Nanogenerator worked by piezoelectric effect,electrostatic induction and contact electrification,pyroelectric effect,as a new type of energy conversion equipment,can not only collect and utilize strong mechanical energy,but convert weak mechanical behavior into electrical energy.Nanogenerator that origined from their excellent mechanical energy conversion,sensitive micro-pressure induction,good biocompatibility,and long-term stability of electrical output have been widely employed in biological monitoring and disease treatment.Among them,the membrane-type nanogenerator,which are soft and have a high mechanical compatibility with the soft tissues in vivo,have realized the energy collection and conversion functions in the animal.However,these membrane-type nanogenerators are too large and easily cause immune rejection during implantation.It is impossible to achieve minimally invasive surgery in actual animal clinical surgery,which severely limits the application of nanogenerators in vivo.Therefore,the development of self-powered electronic devices that can achieve minimally invasive implantation and the establishment of a stable energy conversion system are in great demand.The three-dimensional structure of linear has strong tensile properties and tiny figure,which can be matched with the movement of soft tissues in vivo,and linear-type nanogenerators with excellent performance and high stability can be obtained by designing materials.In this work,a new type of implantable fully-flexible linear-type nanogenerator based on the basic principle of tribo-piezoelectric synergy was prepared through material modification,electrospinning technology and microstructure design.The main research processes are as follows:(1)Construction of linear tribo-piezoelectric hybrid nanogenerator.In order to prepare a linear-type nanogenerator with self-powered performance,flexibility and minimally invasive implantation,an Au NPs/PDMS(nano-gold particles/polydimethylsiloxane)linear friction nanogenerator was obtained through material modification;and the Zn O NPs/PVDF(nano zinc oxide/polyvinylidene fluoride)piezoelectric fiber layer was received on the linear triboelectric nanogenerator by electrospinning technology.The linear tribo-piezoelectric hybrid nanogenerator gained by this preparation process have a stretchability of 99%,and the electrical output of the tribo-piezoelectric synergy is 0.947±0.053 V.The excellent flexibility of the linear tribo-piezoelectric hybrid nanogenerator lays the foundation for monitoring the movement of a wide range of tissues in vivo.(2)Construction of highly sensitive linear tribo-piezoelectric hybrid nanogenerator.In the design process of the linear friction generator,the process of pleated fiber structure was developed.Zn O NPs/PVDF piezoelectric with a pleated fiber structure achieved by the process of pre-stretching the substrate-electrospinning Zn O NPs/PVDF fibre-releasing the substrate.The influence of the pleated fiber layer on the linear triboelectric pressure generator was explored,and highly sensitive linear tribo-piezoelectric hybrid nanogenerator was obtained.The pleated fiber structure significantly improves the electrical performance,pressure detection range and sensitivity of the linear triboelectric nanogenerator.The linear tribo-piezoelectric hybrid nanogenerator has a diameter of only 0.485 mm and can detect the pressure range of 5Pa-40 KPa,which is of great significance to the research and development of minimally invasive implanted electronic devices.(3)Highly sensitive linear tribo-piezoelectric hybrid nanogenerator for micro-pressure sensing and energy conversion in vivo.A set of biological physiological movement monitors were designed,highly sensitive linear tribo-piezoelectric hybrid nanogenerator were minimally invasively implanted into the movement parts of mouse through catheters;and a self-powered brain stimulation system that can synchronize with the physiological state has been designed by integrating highly sensitive linear tribo-piezoelectric hybrid nanogenerator and brain stimulator.Highly sensitive linear tribo-piezoelectric hybrid nanogenerator can be effectively coupled to the squeezing and contraction movement of the muscle and display excellent sensitivity and specificity of the monitoring part.In addition,the electrical pulse generated by the movement effectively acts on the brain electrical stimulator,the increase in EEG signals was successfully triggered,which provides a promising strategy for future bioelectronic devices based on electrical stimulation to treat brain diseases.The research pioneer the design of a three-dimensional fully flexible linear-type nanogenerator that can be implanted in vivo utilizing catheter minimally invasive means for the infinite conversion and collection of mechanical energy into electrical energy in the human body.The three-dimensional structure of linear can sense the various types of mechanical forces generated by the movement of the tissues in vivo,and the immune rejection reaction of the organism are reduced by the implantation method of minimally invasive puncture.The linear-type nanogenerator have great value and influence for the design of electronic equipment used in biological health and treatment.