Prototyping System Development And Field Strength Ex Vivo Verification Of Tumor Treating Fields

As a common malignant disease that endangers human health,cancer shows a trend of continuous increase in incidence and mortality.For cancer treatment,in addition to surgery and radiotherapy,electromagnetic field-based cancer treatment methods are gradually gaining attention and development because of their less invasive and less toxic side effects.Among them,medium-frequency tumor treating fields has received wide attention for its smaller cytotoxicity and comparable efficacy with chemotherapy.In order to facilitate the research related to tumor treating fields,it is important to design a prototype system that can be applied to both animal experiments and cellular experiments.This paper designs and develops a therapeutic prototype system that can be used in animal and cellular experiments to deliver a maximum peak-to-peak therapeutic signal of more than 31 V in the therapeutic frequency range(100 k Hz to 300 k Hz)for tumor treating fields,with adjustable frequency amplitude and the ability to monitor the system output swing during the treatment process.The new treatment electrode with adjusted structure and material can reduce the side effects on the skin caused by the conventional conductive hydrogel-based treatment electrode.Because of the strength dependence of tumor treating field,it is necessary to measure the electric field strength during the actual treatment.However,existing studies lack a method for measuring the electric field strength in the target area,so there is an urgent need to propose an accurate and effective method for measuring the electric field strength in tumor electric field therapy.Based on the method of using s-EEG electrode to measure the electric field generated by transcranial electrical stimulation in some papers,this paper proposes a method to measure the therapeutic electric field using a differential electrode pair,which selects the appropriate electrode diameter and electrode spacing by simulation,and records the swing and phase difference of the differential electrode pair using an oscilloscope to calculate the actual electric field strength.In the ex vivo validation model,the deviation of the measured electric field strength from the simulated electric field strength correction value is less than 7%.Research results are important for the optimization of the subsequent tumor treating fields treatment system and the clinical trials of tumor treating fields.