Study On The Anti-Cervical Cancer Of Tungsten Disulfide Nano-Drug Delivery System Based On Piezoelectric Catalysis

Cancer has been a problem for hundreds or even thousands of years,and many new treatments have emerged in recent years.Due to the advantages of nanomaterials in drug loading,delivery and controlled release,drug delivery relying on nanomaterials has become an intriguing research topic.However,a series of biological obstacles need to be overcome during the circulation,accumulation,penetration,internalization and release of nanomaterials in the body,resulting in insufficient content of nanomaterials reaching the depth of tumors.One of the reasons is the physical barrier formed by the solid extracellular matrix（ECM）of the tumor microenvironment,such as collagen and fibronectin.This dense and sticky matrix seriously hinders the penetration of nanomaterials into the tumor.Another reason is the obstruction of lymphatic drainage in the tumor,resulting in the retention of tumor liquid interstitial fluid,compression of blood vessels,so that the direction of blood delivery of drugs is opposite to the direction of liquid diffusion in the tumor tissue.Therefore,it is important to effectively reduce the pressure of solid and liquid phase of tumor interstitial and reverse the tumor microenvironment to promote the deep penetration of nanomaterials.Tungsten disulfide（WS₂）is a new type of piezoelectric catalytic material,with a typical two-dimensional non-symmetrical structure,which can convert mechanical energy into electrical energy and improve the efficiency of electron migration in two-dimensional semiconductor materials.Due to the interaction of a large number of electrons and holes in the conduction and valence bands,the redox reaction occurs violently.Therefore,the external mechanical force applied to the piezoelectric material can effectively promote the separation of internal charge and improve the efficiency of electron migration in the piezoelectric material,and the electrons and holes formed can provide more energy for the redox reaction.In this study,the piezoelectric catalytic material WS₂ was used as the drug carrier,and Pt nanoparticles were deposited,loaded with curcumin（Cur）,and coated with homologous tumor cell membrane.The Cur-Pt/WS₂@M nanodrug delivery system was constructed.The specific adhesion molecules expressed on the tumor cell membrane can be recognized and bound by the homologous tumor cell membrane,so as to specifically target the tumor site and accumulate in the tumor site.Pt/WS₂ generates a built-in electric field under the action of ultrasound,electrons migrate and are captured by Pt nanoparticles,which enhances the separation efficiency of electron hole pairs.The holes react with water to produce O₂,and the electrons react with O₂ to produce·OH and·O₂^-,reducing the liquid phase pressure and using ROS to kill tumor cells.Cur is an antitumor drug that significantly reduces extracellular collagen production,reduces solid matrix pressure,and ultimately achieves simultaneous hydraulic-solid pressure reduction,facilitating drug penetration.In vivo and in vitro experiments,the Cur-Pt/WS₂@M effectively decomposing and reducing most of the extracellular matrix and water under ultrasound,reducing the pressure at the tumor site by72.4%,and improving the antitumor efficacy.