Chiral Porous Materials Used As Stationary Phases In Capillary Electrochromatography

Chirality is ubiquitous in nature.Most living macromolecules have chirality.Due to chiral medicine molecules,their chemical properties are different,which affect their efficiency and activity.So far,the separation of chiral medicines is very important in pharmaceutical chemistry.The chromatography is more widely used technology in chiral separation.Therefore,three kinds of porous materials were coated on the inner wall of the capillary by dynamic method to make three chiral capillary electrochromatographic columns.The contents mainly included the following aspects:（1）A metal-organic cage MOC-PA with the molecular formula Cu₁₂(L_PA)₁₂（H₂O）₁₂,L_PA=L-phenylalanine,was synthesized.It was used as a stationary phase to prepare a capillary electrochromatographic column.The separation performance of the chromatographic column was investigated to find the best separation conditions.The position isomer o,m,p-nitrophenol and chiral compound zopiclone,4-methyldiphenyl methanol,1,2-diphenylglycol and anisoin were successfully separated.（2）A porous organic cage POC was synthesized and used as chiral stationary phase in electrochromatography.The separation performance of the chromatographic column was also investigated and the optimal separation conditions were explored.The resolutions of positional isomers o,m,p-toluene,o,m,p-chloroaniline and the chiral compounds ofloxacin,trogoline,2-amino-1-butanol and 1-phenyl-1-pentanol were obtained.（3）With the chiral capillary electrochromatographic columns of two three-dimensional covalent organic framework materials CR-COF1 and CR-COF2based on binaphthyl crown ether,the CR-COF1 column could resolve many positional isomers and the chiral compounds diphenylethanone,chlorphenamine maleate and zopiclone;the CR-COF2 column could separate manypositional isomers and the chiral compounds trans-1,2-diphenylethylene oxide,trogoline and zopiclone,respectively.