| Since the 20 th century,with the rapid rise of the Chinese economy and the continuous progress of the medical system,people have paid more attention to the development and problems of medical dressings in the field of wound healing.With the improvement of patients’ requirements for wound healing comfort and the continuous improvement of the medical system,patients’ requirements for wound healing comfort are also gradually improved.Hydrocolloid dressings are widely used in chronic wounds because of their suitable wound exudate absorption,good moist environment maintenance,and ability to accelerate wound healing.At the same time,natural bio-based materials for wound dressings have been continuously developed in recent years,and have certain advantages in water retention,biocompatibility,and therapeutic properties.Konjac glucomannan(KGM)is a plant polysaccharide with good cell compatibility and gel properties.Various gels obtained by modifying KGM by physical and chemical methods have great application potential in wound healing.The combination of KGM with other polymers can improve the problem of poor mechanical properties and give it new functional properties,which is beneficial to moisturizing the wound surface and promoting drug release for wound healing.In this paper,the hydrocolloid dressing based on konjac glucomannan was designed from the molecular structure,and a network structure with good water conductivity was constructed by the synergistic effect of hydroxyl,carboxyl,and other groups on the molecular structure with Chitosan(CS)and Carboxymethyl cellulose(CMC),which further improved the adhesion performance of the dressing in a humid environment.The main research contents are as follows :Firstly,the hydrocolloid dressing based on konjac glucomannan(KGM),sodium carboxymethyl cellulose(CMC),and chitosan(CS)was constructed.The elastomers such as poly(styrene-b-isoprene-b-styrene)(SIS)and polyisobutylene(PIB)were selected to prepare the continuous phase of pressure-sensitive adhesive in the mixer,and then the hydrophilic particles KGM,CS,and CMC were dispersed in the continuous phase by mixing to prepare konjac glucomannan-based hydrocolloid dressing.Due to the electrostatic interaction,the network structure was formed to build a water conduction pathway,which improved the water absorption performance of the dressing.Konjac glucomannan molecules contain a large number of hydroxyl and carbonyl groups,which form strong hydrogen bond interactions with other macromolecules so that KGM can absorb and retain a large amount of water so that KGM gel can provide a continuous wet environment.The adhesion performance of hydrocolloid dressing in a humid environment was enhanced.The results showed that the hydrocolloid medical dressing with the best comprehensive performance was obtained when 7% konjac glucomannan was added,which could reach 450% swelling rate,0.25 MPa tensile strength,2600% elongation at break,and 12.5N/cm peel strength.In addition,The dressing has good infiltration ability proved by the contact angle test.Secondly,the corrosion resistance of the prepared konjac glucomannan-based dressing in the small intestinal fluid was studied.It was found that the prepared KGM-3.5 hydrocolloid dressing still had a relatively complete structure and hydrophilicity after corrosion in small intestinal fluid,and could resist the corrosion of trypsin and weak acid in small intestinal fluid.The tensile strength of the dressing after intestinal fluid corrosion can still reach 0.20 MPa,and the elongation at break can reach 1800%.It overcomes the problem that the mechanical properties of general hydrocolloid dressings decrease greatly after intestinal fluid corrosion.At the same time,it can maintain its bonding performance in the environment of small intestinal fluid corrosion,which can achieve 6 N/cm peeling strength and 35 min holding time.It is concluded that the prepared dressing can be practically applied to the ileostomy bag chassis dressing resistant to small intestinal fluid corrosion. |
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