| The State Council issued the regulation<Cosmetic Supervision and Administration Regulation>in 2020,which clarifies that cosmetics should comply with the excellent quality standard.Microbiological control is one of the keys focuses in the quality management system.Several elements in the manufacturing process impact microbial performance.Therefore,how to produce good quality cosmetic products consistently now attracts high attention in the industry.Firstly,this article compared the traditional microbiological testing method and the new rapid testing method.Secondly,it analyzed the microbe contamination source and the trend in the manufacturing process.Thirdly,it discussed how to improve the formula microbic robustness and optimize the manufacturing cleaning and sanitization activity parameters.The primary conclusions are as below:(1)MicroBio3D is a microbial colony counting system including colony determination and counting ability.Four different microorganisms as the testing strain were used to examine the consistency of the traditional visual counting method and the instrument counting method also the impact of impurities in a sample on instrumental reading.The result showed a significant positive correlation(R~2=0.85-0.99,p<0.05).The reading between the visual count and instrument count is very close.Furthermore,instrument counting is more sensitive and rapid.Charm is an instrument to detect the equipment surface after the cleaning and sanitization using the ATP(adenosine-triphosphate)technology.The result showed that Charm testing is a reliable and rapid method.It can replace the traditional swab test after the equipment is sanitized.(2)From 2010 to 2020,the cosmetic bioburden trending of raw materials,water,compressed air,environment,semi-finished products,equipment surface bioburden,and finished goods products in production was analyzed.It was found that different factors played a leading role in different periods.Once a particular element is abnormal,it would impact the finished product’s micro performance.From 2018 to 2020,microbial growth trends on equipment surfaces were positively correlated(p<0.05)with growth trends in finished products.It was the dominant factor in the contamination source.(3)The ingredients in the formula determine the antibacterial capability of the formula itself.The water activity can be used as an essential indicator for evaluating the antibacterial capacity of the formula.The article studied the water activity for different groups of raw materials.It showed that the following raw material could reduce water activity in the product formula.They are magnesium aluminum silicate,glycerin,potassium chloride and sodium lauryl sulfate.The cosmetic formula used the orthogonal experimental to perform the micro robustness test in the formula design phase.The result showed that one particular formula by adding 5%sorbitol,10%glycerin,0.5%sodium pyrophosphate,0.5%sodium tripolyphosphate,and 0.2%Benzyl alcohol was an optimization point to increase the antibacterial capability.(4)The good practice of cleaning and sanitization can reduce the risk of microbial contamination in the manufacturing process.The 360-degree rotating spray ball can deliver the strongest cleaning action.In the cleaning phase,it can achieve visual cleaning using 5%cleaning reagent under 60℃temperature with 30 minutes of circulation time.In the sanitization phase,using 0.1%peracetic acid under room temperature with 10 minutes of circulation time can deliver excellent sanitization results.To sum up,the automation microbiological testing method can count the number of microorganisms more rapidly and accurately than visual counting.It can meet the cosmetic supply chain requirement of rapid response and inventory reduction.Analyzing the manufacturing process’s key elements,adjusting the formula ingredient and dosage and optimizing the equipment cleaning and sanitization process can reduce the risk of microbiological contamination and improve product quality. |
