Base Promoted Reaction Of N-tosylhydrazones With Electron-deficient Olefins

In recent years,N-Tosylhydrazones has become a key component in the development of new transition metal-catalyzed or transition metal-free conversion,and is an emerging component in the current field of organic chemistry.It is a derivative of a class of carbonyl compounds,which is easy to crystallize,easy to purify,and stable as a synthetic intermediate,and can be used as a precursor of diazo compounds and carbenes.Because it is easy to produce,it is widely used in the process of transition metal catalysis and non-metal catalysis to construct carbon-carbon bond and carbon-heterous bond to prepare compounds with pharmaceutical biological activity.Therefore,it is of great research value to develop new non-metallic catalytic N-Tosylhydrazones reaction.The essential contents of this thesis are as follows:In the first part,the study on Tandem reaction of N-Tosylhydrazones and para-Quinone Methides(p-QMs)in the presence of Na OH is mainly described.This reaction is characterized by easy availability of raw materials,mild conditions,and simple operation,resulting in the synthesis of a series of(1E,3Z)-azoalkene compounds with good yields(up to 99 %)and complete selectivity.In the second part,the reaction of N-Tosylhydrazones with electron-deficient alkene pyrazolone derivatives in the presence of Na OH was mainly described.This reaction strategy has been implemented to synthesize a series of(1E,3Z)-azoalkene compounds from easily synthesized N-Tosylhydrazones and electron deficient olefins,providing a new method for the synthesis of azo compounds with simply safe operation and excellent yield.