Upconversion Nanoplatform With The Properties Of Light-Controlled Release Of Nitric Oxide For The Treatment Of Parkinson’s Disease

This paper mainly discusses the preparation of gas delivery platforms using gas donors(nitric oxide donors),near-infrared light responsive materials(upconversion nanoparticles)and biomimetic biofilms(red blood cell membranes),along with its applications in the treatment of Parkinson’s disease(PD).PD is a class of neurodegenerative diseases with complex pathogenesis,and it is also the second largest neurodegenerative disease in the world.This disease easily leads to movement disorders,which brings many inconveniences to patients and their families.Currently,treatment methods such as levodopa instead of therapy and deep electrical stimulation are mainly used to alleviate movement disorders caused by the disease and improve the quality of life of patients,but no effective means have been found to prevent or reverse the progression of PD.The blood brain barrier and the complex inflammatory environment in the brain are two major challenges in the treatment of PD.To address the two challenges,we have designed a gas therapy platform that used red blood cell membranes as target groups,to modify the surface of upconversion nanoparticles coated with mesoporous silicon and loaded with nitric oxide donors(Snitrosoglutathione,GSNO).This platform can effectively target the brain.Irradiation with 980 nm near-infrared light(NIR)stimulates upconversion nanoparticles to emit green light(540 nm),which promoted GSNO to release nitric oxide,reduced the level of pro-inflammatory factors in the brain,and produced a light-responsive antiinflammatory effect.Both in vivo and in vitro experiments have demonstrated that the delivery platform can effectively alleviate inflammatory response damage in the brain.Theoretically,this method can reduce the damage to neurons caused by the secretion of proinflammatory factors,and has potential in future clinical applications.