Design,Synthesis And Properties Of Nucleobase-functionalized Polymers

DNA is an important genetic material in life.The specific hydrogen bond recognition of nucleobases plays an important role in determining relevant transcription,translation,and replication functions in nucleic acid chemistry,and provides more possibilities for biological and material science research.In recent years,nucleobase-functionalized polymers have been widely developed into self-healing materials,supramolecular adhesives and stabilizers of metal nanoparticles.Plasmonic nanoparticles exhibit unique physicochemical properties,such as high extinction coefficient in visible region,fluorescence quenching effect,huge specific surface area and strong local surface plasmon resonance(LSPR)absorption,which have fostered broad applications in the biomedical field.On the other hand,DNA can be used as a perfect ligand to modify metal nnaoparticles(MNPs)to maintain a high colloidal stability in complex environments.In addition,modified nanomaterials can exhibit properties that differ from the MNPs and DNA from which they derive.In this thesis,nucleobase-functionalized monomers were synthesized to prepare corresponding nucleobase-functionalized polymers,which were further applied to protect a series of metal nanoparticles.The performance of nucleobase-functionalized polymers to stabilize nanoparticles was further evaluated in different temperature,p H and ionic environments.In addition,the stability and solvation properties of MNPs in organic solvents were also investigated,and the phase transfer of MNPs stabilized by nucleobase-functionalized polymers from aqueous phase to organic phase was further demonstrated.Last,copolymerization of nucleobase-bearing monomers with different functional monomers provided opportunities to prepare functional polymers with novel properties.