Risk Safety Assessment Of Aspartame Based On Benchmark Dose Method

Aspartame is a commonly used low-calorie sweetener widely applied in the food industry.However,due to its abuse and the insufficient strictness of current standards,an increasing amount of research suggests that aspartame may pose potential risks to human health.Therefore,this study reevaluated the safety of aspartame and provided scientific evidence for the establishment of stricter usage standards.To achieve this,we evaluated the dose-response relationship of aspartame using the benchmark dose(BMD)method,by reviewing literature and experimental data.We calculated the acceptable daily intake(ADI)value using animal toxicological experiments and human epidemiological experiments,which was more conservative than the current ADI value(40 mg/kg BW)based on the no observed adverse effect level(NOAEL)method.Based on animal toxicological experiment data,we used the classical BMD model of binary data types to simulate and deduce the human ADI,which was 1.3mg/kg BW.Further optimization was conducted using the Bayesian model averaging algorithm,resulting in an ADI of 1.7 mg/kg BW.Based on human epidemiological experiment data,we simulated the classical BMD model of continuous data types for both the normal population and PKU heterozygous population.The ADI was 25.13 mg/kg BW for the normal population and 10.42 mg/kg BW for the PKU heterozygous population.Compared with simulating the animal toxicological experiment data,using human epidemiological data directly for simulation did not require dividing by the uncertainty coefficient,and thus,the resulting ADI value was more referential.We also evaluated the exposure of dietary consumption data of aspartame and found that the usage amount of aspartame has increased in recent years,with daily exposure levels exceeding the ADI for the normal population,which poses a significant risk.Therefore,this study proposes the recommendation of strengthening public awareness and consumption guidance on aspartame food safety.