Asymmetric Synthetic Studies Of (-)-Merrilactone A

Up to now,humans have isolated a variety of active ingredients with unique biological activity such as terpenes,lignin,and phenylprophetin from illicium.Among them,various terpenes are the most,with more than200 species.Studies have confirmed that a considerable number of illicium terpene natural products have excellent biological activity in insecticide,antibacterial and anti-inflammatory,neurotrophic and other aspects,and have great potential for use.This paper takes Anislactone-type sesquiterpene(-)-Merrilactone A,which has good nerve growth promotion activity,as the research object,and mainly includes the following three parts:Chapter 1: This chapter briefly reviews the history of terpenes,explains the important role of terpenes in humans,and introduces the unique structure and synthesis challenges of natural products of sesquiterpenoids of the illicium.Chapter 2: This chapter systematically describes the discovery,isolation,activity,and biosynthetic hypothesis of Anislactone-type sesquiterpenes of the star anise genus,and provides a comprehensive overview of the reported total synthesis of the target molecule(-)-Merrilactone A.Chapter 3: This chapter details the process by which our group has continuously tried and finally explored a pathway for the synthesis of racemic merrilactone A molecular formsChapter 4: This chapter details our work on the asymmetric reduced Heck reaction in the exploration of asymmetric synthesis of merrilactone A molecules,including the synthesis of novel chiral phosphine ligands and the screening of reaction conditions.