Synthetic Studies On Synthesis Of Fortuneicyclidins A And B

The synthesis of Fortuneicyclidins A and B containing oxygen at C11 was studied in this paper.The full text consists of the following two chapters:Chapter One: Synthesis of Cephalotaxine,11-hydroxycephalotaxine and their derivativesThe first section mainly introduces five strategies for cutting bonds in the B ring of Cephalotaxine molecule,which basically have the core skeleton of Dolby-Weinreb amine or azane 5/5 spiro ring.The second section briefly introduces three synthesis routes of research on the synthesis of 11-hydroxycephalotaxine and its derivatives by four research groups,respectively.Chapter Two: Synthesis of Fortuneicyclidins A and BThe biological activities,structural characteristics,genetic transformation and synthesis of Fortuneicyclidins A and B were briefly reviewed.We completed the synthesis of the precursor of Cephalotaxine through four generations of synthesis route.