| Alginate is the most abundant renewable biopolymer in the ocean,and the development and utilization of its high-performance materials is one of the important means for mankind to cope with fossil-based energy depletion.Alginate sponge materials not only maintain the potential bioactivity and biocompatibility of alginate,but also have the concomitant advantages conferred by the high porosity and large specific surface area of sponge materials.Currently,it has been studied extensively in areas such as trauma treatment,drug release,tissue engineering and sewage treatment,but there are still process and performance deficiencies for replacing fossil-based polymer materials.It is a viable solution to develop high performance alginate sponge materials combined with mature nonwoven processes.In this paper,the structure of calcium alginate(CA)freeze-dried sponge is optimized by using fluffy,soft and high-porosity through-air thermal bonded nonwovens(NWs),proposes a structurally controllable high-performance sponge material preparation scheme.Combined with nano-supported natural antibacterial substances eugenol and atomization sputtering technology to give the sponge material long-lasting fragrance-releasing antibacterial properties and verify the application potential in trauma treatment.The study includes the following main sections:(1)Based on the improvement of the structure of CA sponge by NWs skeleton,the influences of different preparation processes on the properties of composite sponge(CA@NWs)were analyzed.NWs skeleton can improve the forming structure and size of freeze-dried calcium alginate sponge,which is regulated by pre-freezing temperature and preparation concentration.In view of the fact that alginate sponges are mostly used in wet liquid environment systems,the influence of structural regulation on liquid interaction properties such as liquid absorption,moisture permeability,moisture retention and liquid transfer of composite sponges were analyzed,and their dry and wet state mechanical properties were characterized and analyzed.The tensile strength of 1.5wt% wet rapid-frozen CA@NWs sponge is 1.913 and 0.465 MPa in MD and CD directions,respectively,which is about 95 times higher than that of wet pure CA sponge.(2)To enhance the antibacterial ability of composite sponges,trauma treatment applications were explored.A modified St(?)ber method was used to prepare mesoporous silica nanoparticles(MSNs)carriers with a particle size range of 100-200 nm,a pore size of 6.54 nm and a specific surface area of 998.05 m2/g.Aromatic antimicrobial nanoparticles(EG@MSNs)were prepared by nano-supported loading of natural active antimicrobial substance eugenol essential oil(EG)with 57.085% loading,which effectively improves the thermal stability of EG and achieves long-lasting slow-release effect.The immediate dissolution of EG@MSNs was tested in the trauma tissue simulation solution,and the dispersive concentration of about 2.35mg/m L can reach the immediate dissolution level of excess EG direct drops.It could be combined with the healing requirements of wound moistening to create a rapid antimicrobial fluid microenvironment.(3)EG@MSNs were uniformly loaded onto the CA@NWs sponge surface by atomized sputtering technique,and the potential of the finished product for trauma care applications was verified by bacterial inhibition,coagulation and various medical standard tests.The results showed that the aromatic functionalized CA@NWs sponge had E.coli inhibition for more than 15 days.Depending on the preparation process,the coagulation time of CA@NWs can be reduced by57.1% ～ 71.4%.In the fluorescent substance,surface active matter,water soluble matter and PH test of water leaching solution are all in line with the requirements of the relevant medical industry standards. |
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