From Symmetrical Tetrasulfides To Disulfides

Unique disulfide bonds endow disulfide compounds with unique chemical properties.For example,sulfur sulfur bonds can be used to construct molecular s 表structures of proteins or natural products in living organisms;It is used as food additive in the field of food chemistry and essence;Acting as a reversible linker or active site for coupling drugs and as a fluorescent probe for identifying and characterizing the location of cancer lesions.Because disulfide compounds have such a wide range of applications,they have attracted numerous scientific researchers’ attention and exploration for the efficient construction of disulfide compounds.However,in the literature reports on the construction of symmetric or asymmetric disulfide compounds at home and abroad,it is difficult to avoid the following shortcomings: mercaptan/thiophenol raw materials have an intolerable odor,reaction by-products are difficult to avoid,the synthesis of disulfide reagents is cumbersome,reaction conditions are harsh,substrate universality is poor,the preparation of corresponding disulfide reagents is difficult,and the effect of light amplification preparation is poor.In response to these issues,the research phase of my master’s thesis attempts to successfully construct an electrophilic disulfide reagent from an easily available and relatively odorless raw material through mild light energy excitation to solve the problems of poor stability of tetrasulfide and multiple substrate fracture sites.During the reaction process,we use the photoreactor designed and built by our team to construct asymmetric disulfide reagents by selectively breaking easily available and relatively odorless symmetric tetrasulfide compounds,taking advantage of the advantages of light environment friendliness,high controllability,safety,convenience,and sustainability.In response to the national call for low-carbon development,we have attempted to achieve controllable,efficient and selective fracture of tetrasulfide under mild,green and environmentally friendly controlled blue LED light irradiation conditions using environmentally friendly solvents without any additives.We have attempted to construct disulfide reagents with a thiosulfone structure,in which the sulfone group serves as a leaving group and can be used for further reagent applications.At the same time,it is trying to expand its biological application value by applying disulfide bonds to the connection of amino acids,drugs,or terpene compounds.In order to solve the problem of poor reaction effects in light reaction amplification,we tried to use the optofluid instrument independently developed and designed by our group to verify the reaction effects of industrial scale amplification preparation.