MOFs-Based Multifunctional Catalysts For Multi-Step Sequential Reactions

Metal-Organic Frameworks（MOFs）have shown great application prospects in heterogeneous catalysis,because of their highly adjustable ligands and pores.Until now,the monofunctional MOFs-based catalysts have been well-studied,however,the multifunctional MOFs-based catalysts are still in the development stage.Meanwhile,the preparation of trifunctional catalysts that combine the alloys’synergistic effect and the MOFs frameworks’modification is rarely reported.Herein,this paper mainly focuses on the following two aspects:（1）CuCo nanoparticles（NPs）were successfully prepared from metal salts by hydrothermal reduction.Bipyridine dicarboxylate was chosen as the organic linker,which was facile to be coordinated with PdCl₂（CH₃CN）₂.L-proline was used as the chiral source,and the multifunctional chiral catalyst CuCo@UiO-67-Pd（Ⅱ）-L-Pro was prepared by the one-step method.A series of characterizations were used to verify the successful synthesis of the catalyst.（2）The catalyst was used in the Aromatic alcohol oxidation-Suzuki coupling-Asymmetric aldol multi-step sequential reactions,and it showed high yields and high ee_anti values(the yield of the oxidation reaction reached 95%,the coupling yield reached 96%,the asymmetric yield reached 62%,and the ee_anti value reached 73%).Moreover,the catalyst could keep the structure unchanged during the catalysis,suggesting its high recyclability and reusability.In this paper,a trifunctional chiral catalyst was designed and prepared,which combines three active substances within UiO-67.The prepared catalyst was applied to asymmetric sequential reactions.The trifunctional catalysts constructed by taking advantage of the framework tunability of MOFs and the synergy of bimetallic alloys are of great reference value for the rational design and successful preparation of novel multifunctional composites.