Preparation Of Metal-organic Frameworks Composite Aerogel And Its Analysis And Removal Of Drug In Water

Drugs are widely used to prevent and treat human and veterinary diseases,but due to improper use and lack of effective supervision,more and more drugs are released into environmental waters.Residual drugs in environmental water have toxicity and bioaccumulation,they will threaten human health and the ecological environment.Therefore,it is urgent to analyze,detect and remove drugs in water.Metal-organic Frameworks(MOFs)possess the advantages of large specific surface area,various types,and high chemical and thermal stability,but powdery MOFs are difficult to be separated from the liquid phase during the sample pretreatment and adsorption removal process.Metal-organic Frameworks aerogel composite materials combine the efficient selective adsorption performance of MOFs and the large pore volume of aerogel.Thus,MOFs aerogel can be used as an efficient adsorbent for the analysis and adsorption of contaminants in environmental water.They can be prepared in monolithic form,which makes the solid-liquid separation more convenient.In this paper,two new MOFs aerogel composite materials were synthesized for the analysis of non-steroidal anti-inflammatory drugs in water and the removal of oxytetracycline respectively.(1)A novel MOF/chitosan(CS)composite designated Co-Ui O-67(bpy)/CS was prepared as the adsorbent material to enrich ketoprofen(KPF),naproxen(NPX),flurbiprofen(FPN),diclofenac(DCF),and ibuprofen(IBF)in water.Combined with ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS),a novel method for the detection of drug residues in environmental water based on MOF_Scomposite aerogel was established.To achieve the best extraction efficiency,the main factors affecting extraction efficiency were investigated and optimized.The optimized results showed the target compounds can be completely adsorbed within 5 minutes,and can be fully desorbed by elution of 1%formic acid at a total volume of 5 m L.The analytical method was established in the optimized extraction conditions.The five NSAIDs displayed good linearity with linear correlation coefficients greater than 0.9937.The limits of detection(LOD)and limits of quantification(LOQ)of this developed method were 0.32-2.06 ng/L and 1.05-6.78 ng/L,respectively.The method was then used to test real-world water samples.The method exhibited good sensitivity,accuracy,and precision,and the operation process was convenient.The present study thus presents a novel method for the detection of the trace NSAIDs in environmental waters.(2)Cu-BTC was synthesized by a solvothermal method.Cu-BTC and calcium carbonate particles were uniformly dispersed in sodium alginate(SA)solution.Cu-BTC/SA aerogels were prepared by sol-gel,solvent exchange,and ambient drying process.Cu-BTC/SA aerogels were utilized for the adsorption removal of Cu-BTC/SA oxytetracycline,which is one of the most widely used tetracycline antibiotics.Cu-BTC/SA was characterized by XRD,FT-IR,SEM,and contact angle measurements.Several adsorption influencing factors,adsorption properties,and adsorption models were investigated.The results show that oxytetracycline adsorption fitted with the Pseudo-second-order kinetics model.The adsorption isotherm showed that oxytetracycline adsorption fitted with the Langmuir adsorption model,and the maximum adsorption capacity was 316 mg/g.After adsorption,Cu-BTC/SA can be easily separated from the aqueous solution without,the adsorption process will not result in secondary pollution to the environment.