Reaction Study On Synthesis Of Quinoxaline From Ortho-phenylenediamine And Acetophenone Or Benzaldehyde

Quinoxaline derivatives are important N-containing heterocyclic compounds whose structures are widely found in natural products,biomolecules and optoelectronic materials,and have important applications in many fields.Quinoxaline is an important building block for the synthesis of new heterocycles and an important intermediate for the synthesis of biologically active compounds,which is of great significance in related fields such as organic chemistry and medicinal chemistry.In this paper,various methods for synthesizing quinoxaline compounds from two aspects of metal catalysis and non-transition metal catalysis are introduced,the structure and synthesis of quinoxaline derivatives are introduced,and a green efficient synthetic aromatic A method for quinoxalines.The main content is explored and researched from the following two aspects:1.In the ^tBuONa/DMSO/O₂ system,without the participation of transition metals,acetophenone and o-phenylenediamine are used as substrates for the reaction to obtain quinoxaline compounds in moderate to good yields,which have various functional groups.With good tolerance,it is a green and efficient method for synthesizing quinoxalines.2.Under the same system,we introduce a new method for synthesizing quinoxalines using benzaldehyde and o-phenylenediamine as substrates,DMSO as solvent and reaction carbon source.The reaction does not require transition metal catalysis and additives,and various quinoxaline compounds can be obtained under mild conditions.The method has the advantages of simple operation,mild reaction conditions and easy-to-obtain raw materials,and is a novel method for synthesizing quinoxalines.