Visible Light-induced Photocatalyst Participation In The Synthesis Of Polyfluoroalkyl Compounds From Cyclopropane Derivatives

With the progress of organic synthesis and modern medicine,more and more once impossible is being overcome by research scholars one by one.Among them,the most concerned is undoubtedly the medical research progress.Medical research progress not only relies on technical means,but also requires effective drugs as support.In the current medical field,fluorine-containing drugs occupy a considerable proportion.In view of the unique structure and properties of cyclopropane,its ring-opening ability,including structural modification ability,is first-rate.The research of this experiment focuses on the dual-activated alkenyl cyclopropane,and attempts to establish the basis of the molecular basis of the substrate with such a structure.In the above,develop a green and gentle method that does not require photocatalyst catalysis and can occur only under the induction of visible light to realize the synthesis of a series of polyfluoroalkyl compounds.Selecting double-activated alkenyl cyclopropane as a series of substrates,and synthesize a series of 1,5 with potential biological activity through the combination with perfluoroiodobutane and a green and mild visible light-induced free radical reaction pathway.Hydrogenated polyfluoroalkylation products.The reaction pathway can be completed in a short time without photocatalyst catalysis;a series of 1,5-hydropolyfluoroalkylated products are synthesized with a high yield.Through control experiments,spectral analysis and other means,the mechanism has been studied.The results show that the reason why this reaction path can proceed smoothly and successfully achieve conversion without photocatalyst only relying on visible light induction is that the main reason may be that EDA ligands replace traditional photocatalysts to absorb visible light energy and stimulate subsequent reactions.Among them,the EDA complex formed between the sacrificial reagent and the target product,and the sacrificial reagent and the oxidation product of the sacrificial reagent are the key to the reaction.The reaction path can be carried out by sunlight instead of blue LED,and the yield of the product is not affected.Such light source conditions make the reaction path more economical and environmentally friendly,which is of great significance.The product yield in the gramlevel reaction does not decrease but increases,indicating that this reaction path has great potential for scale-up and provides a very valuable approach for industrial production.