Synthesis And Glucose Responsiveness Of (Phenylboronic Acid)-Based Poly (Ionic Liquid)Microgels

As we all know,glucose as a vital carbohydrate in nature,is closely related to human production and life.Glucose metabolism is an indispensable part of the metabolic activities of multicellular organisms.The imbalance of glucose metabolism regulation can lead to a series of diseases.Therefore,it is of great significance to realize convenient and accurate measurement of glucose metabolism in biological tissues.In addition,the development of methods and materials that can be used for efficient and intelligent detection of glucose,and even flexible devices,have always been an important research topic.Glucose-responsive microgels are a type of system that can quickly respond to changes in glucose concentrations and simulate biological systems to give feedback.They can be used as the core material of sensors and are expected to be applied to construct electrochemical flexible devices.However,the current glucose-responsive(phenylboronic acid)-based microgels are almost all based on non-conductive systems such as poly(N-isopropylacrylamide)(PNIPAM),which obviously greatly limits the further application of(phenylboronic acid)-based microgels.As a special type of polyelectrolyte,poly(ionic liquid)s have developed vigorously in recent years.Based on their excellent physical and chemical properties and highly integrated multiple interactions,this thesis mainly centered around(phenylboronic acid)-based glucose-responsive microgels.Focusing on introducing poly(ionic liquid)s with ion pairs and adjustable properties into the framework of microgels,a variety of(phenylboronic acid)-based poly(ionic liquid)microgels have been prepared.And then we preliminary explore the use of covalent effect of phenylboronic acid and non-covalent effect of poly(ionic liquid)s to identify glucose synergistically,so as to lay the foundation for the subsequent expansion of(phenylboronic acid)-based microgels in electrochemical glucose sensors and other related fields.The main research contents are as follows:(1)Design and synthesize(phenylboronic acid)-based poly(ionic liquid)microgels with different morphologies through electrochemical potentiostatic polymerization.The glucose responsiveness of(phenylboronic acid)-based poly(ionic liquid)microgels with different morphologies was studied.The characterization results indicated that the long-stick shaped microgels swelled after adding glucose,while the cubic-shaped microgels behaved as contraction.(2)The temperature-sensitive ionic liquid tetrabutylphosphonium styrenesulfonate(TPSS)was copolymerized with 4-vinylphenylboronic acid.In the presence of glucose,take advantage of the net positive(negative)charges generated by the system at different temperatures to realize temperature controlled glucose responsive phase transition of microgels.The resulting microgels exhibited high glucose selectivity in a physiological environment.In addition,the signal generated by the glucoseresponsive phase transition of the microgels can also be converted into electrical signal output.(3)The glucose recognition unit phenylboric acid was placed in a solution containing microgels,the small molecule solute phenylboric acid and the poly(ionic liquid)microgels produced a certain non-covalent reaction.And then the combination of phenylboric acid and glucose was further used to induce the poly(ionic liquid)microgels to generate glucose-responsive phase transition behavior.This innovative strategy provides a new idea for the design of glucose-responsive poly(ionic liquid)microgels.