Catalytic Asymmetry Construction Of Tetrahydro-β-carboline Skeleton Compound And Study On Synthesis Of New Pyrrole Compounds With Potential Anti-obesity Activity

In recent years,nitrogen-containing heterocyclic compounds have played an extremely important role in the research and development of drugs and active molecular compounds,and the synthesis of such compounds has also attracted more and more attention.The research of this paper mainly focuses on two aspects:1)Lewis acid-catalyzed asymmetric[3+3]cycloaddition reaction of aziridine and 2-indolepropenone compounds to construct chiral tetrahydro-β-carba Porphyrin skeleton compound;2)Design and synthesize a series of new pyrrole compounds with potential anti-obesity activity starting from phthalimide,acid chloride and terminal alkyne.In the first part of the work,the asymmetric[3+3]cycloaddition reaction of aziridine and 2-indolepropenone compound under Lewis acid catalysis was achieved,with moderate to excellent yields(up to 98%),Moderate to excellent diastereoselectivity(up to>20:1 dr)and enantioselectivity(up to 95%ee)synthesize a series of chiral tetrahydro-β-carboline skeleton compounds This reaction provides a practical,efficient and convenient new method for the asymmetric synthesis of tetrahydro-β-carboline skeleton compounds with various structures.In the second part of the work,based on the previous work of this group,starting from three cheap and easily available raw materials phthalimide,acid chloride and terminal alkyne,the synthesis was obtained with a maximum yield of 22%after a maximum of 9 steps 17 new pyrrole compounds with potential anti-obesity activity.At present,the biological activity test of the compound is in progress,which provides an idea for the development of new anti-obesity drugs.