Synthesis And Drug Release Study Of Mesoporous Silica

In recent years,inorganic carrier materials have been developed rapidly.Mesoporous silica has attracted the attention of many researchers due to its advantages such as construction stability,good biocompatibility,and efficient drug loading.At present,mesoporous silica has been widely used to improve the dissolution rate of the water insoluble drugs.However,it still needs to further explore the effect of the morphology of mesoporous silica and the mesoporous silica composite on the dissolution rate of the water insoluble drugs.In this study,mesoporous silica with different particle sizes was synthesized by changing the reaction conditions.Then the lipid membrane was wrapped on the outer layer of mesoporous silica to prepare lipid-coated mesoporous silica.The effects of mesoporous silica and lipid-coated mesoporous silica on the solubilization and release of water insoluble drugs were studied.In this study,hydrothermal synthesis was used to synthesize ordered mesoporous silica MCM-41,and the morphology of the products was detected by dynamic light scattering（DLS）,X-ray of diffraction（XRD）,and transmission electron microscopy（TEM）.This study systematically explored the effects of the synthesis conditions,such as stirring speed,TEOS dosage,and ammonia water dosage,on the particle size,dispersion characteristics,and orderliness of the final products,especially the effect of the reaction conditions on the particle size.N₂ physisorption,Fourier transform infrared spectroscopy（FT-IR）,differential scanning calorimetry（DSC）and X-ray of diffraction（XRD）were used to characterize the changes in physicochemical properties of mesoporous silica before and after curcumin loading.The in vitro release results of the drug delivery system were recorded in detail,and the effects of particle size on the curcumin release were summarized.Finally,a new drug carrier system was prepared by enwrapping phospholipids on the outer layer of mesoporous silica with a thin film hydration method.Then,the in vitro release of the new drug carrier system was investigated.The results showed that MCM-41 with a particle size range of 284 nm-845 nm can be successfully synthesized by adjusting the reaction conditions.The particle size of the final products decreased with increasing stirring speed,decreasing TEOS usage,and decreasing ammonia usage.At the same time,it was found that chiral mesoporous silica could be prepared in an extremely dilute aqueous ammonia solution,and its morphology could be controlled by changing the amount of ammonia water added.According to the results of in vitro release experiments,it could be seen that all three sizes of mesoporous silica significantly increased the release of curcumin.The in vitro release rate of curcumin might be also affected by the distribution of curcumin in the carrier.The lipid membrane was wrapped on the surface of the mesoporous silica,which could block the mesoporous channels and effectively reduce the early sudden release of curcumin in the release medium.Therefore,the findings of this study provide a reference for the application of mesoporous materials in the field of controlled release of drugs.