Study On Self-powered Wearable Biosensor For Monitoring Neonatal Jaundice

Neonatal jaundice is a disease that may recur within the first few weeks of birth.Because of its harm to newborns,parents must pay attention to this disease.Traditional blood extraction detection can not achieve real-time monitoring,so there is an urgent need for a device that can monitor neonatal jaundice in real time under independent work,and preferably can be worn on newborns.In this thesis,a self-powered wearable biosensor in baby diaper for real-time monitoring neonatal jaundice has been realized by the coupling effect of solid-liquid contact electrification(L-S CE)and biosensors of ZnO nanoarray.Without external power supply,the system can work independently,and the L-S CE output can be treated as both the power source and biosensing signal.The working mechanism is that the L-S CE output arises from the urine flowing on ZnO nanoarray and the enzymatic re-action on the surface can influence the output.The sensing information can be transmitted through a wireless transmitter,and thus the parents and doctors can treat the neonatal jaundice of baby in time.This work can potentially promote the development of next generation of biosensors and physiological monitoring system,and expand the scope of self-powered technique and smart healthcare area.The specific research contents are as follows:Based on the coupling effect of L-S CE and biosensors of ZnO nanoarray,a selfdriving bilirubin sensor was designed and manufactured.ZnO nanoarray grown vertically on PDMS films were prepared by hydrothermal method,and modified with bilirubin oxidase to make them have the sensing function for bilirubin.The energy generation mechanism of the sensor is described in detail,and the sensing principle is speculated and experimentally verified.The performance of the bilirubin sensor is measured.The experiment shows that the output voltage of the sensor has a negative correlation with the sodium bilirubin in the solution.The experiment proves that the sensor has the required sensitivity,repeatability in a period of time,and specificity for sodium bilirubin in the solution.The output voltage will not be affected by other typical substances in the urine.The factors that need to be considered in the actual use of the self-driving bilirubin sensor have been verified through experiments,and the experiments simulating the actual use have been carried out.The influence of temperature on the bilirubin sensor was explored by experiments at different temperatures.The detection limit of the sensor is verified by experiments.Finally,the process of real-time monitoring jaundice is simulated by connecting the signal processing and analysis module,and demonstrate the early warning function of the jaundice monitoring system using LED indicators as visual sensing information.